ID I3MM48_ICTTR Unreviewed; 1062 AA.
AC I3MM48;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Period circadian regulator 3 {ECO:0000313|Ensembl:ENSSTOP00000012561.3};
GN Name=PER3 {ECO:0000313|Ensembl:ENSSTOP00000012561.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012561.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000012561.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01079073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01079074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01079075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MM48; -.
DR STRING; 43179.ENSSTOP00000012561; -.
DR Ensembl; ENSSTOT00000014020.3; ENSSTOP00000012561.3; ENSSTOG00000014007.3.
DR eggNOG; KOG3753; Eukaryota.
DR GeneTree; ENSGT00940000160817; -.
DR HOGENOM; CLU_006667_0_1_1; -.
DR InParanoid; I3MM48; -.
DR OrthoDB; 2971905at2759; -.
DR TreeFam; TF318445; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IEA:Ensembl.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR048814; Per1-3_PAS-A.
DR InterPro; IPR022728; Period_circadian-like_C.
DR PANTHER; PTHR11269; PERIOD CIRCADIAN PROTEIN; 1.
DR PANTHER; PTHR11269:SF13; PERIOD CIRCADIAN PROTEIN HOMOLOG 3; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF21353; Per3-like_PAS-A; 1.
DR Pfam; PF12114; Period_C; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 226..272
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 671..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..882
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1062 AA; 115983 MW; DBD68D7A05D4FAED CRC64;
MVVQEMKKYF PAERRSKPST LDALNYALRC VRSVQANSEF FQIHNLNGAP EREVTVYSLK
ELATVASELT SKNTDTFVAV FSFLSGRLVH ISEQAALILN CKKDFLKSCH FVDLLAPQDV
RVFYTHTARA QLPFWSSWSQ RASQYECAPV KPFFCRIRGG GGREHEKHYS PFRIIPYLVH
VHSSTQPESE PCCLTLVEKI HSGYEAPRIP VDKRIFTTTH TPGCVFLEID ERAVPLLGYL
PQDLTGTSVL ACLHPEDRPL MVTMHQKVLK YAGHPPFEHS PIRFCTQNGD YIILDSSWSS
FVNPWSRKVS FIIGRHKVRT SPLNEDVFAT RIKKTNSNEK DITELQEQIH RLLLQPVHVS
TSSGYGSLGS SGSQELQVSV DSSSESSGHC LEEVQKEPMT LKQVYSSVNK IKNLGQQLYI
DSMARSSVKP VMGTCPEPSG GDEQKASSSS LTLKNKCTCT EFCEDLRKDQ HSSSYQQMNC
IDSVIRYLKS YHIPALKRKC VSSTNTMASS SEEEKPSHQA DDTQAVQAVA QTPAMPQPKV
PTNGRPTEAE ADLAGTLSTA TLSLGSGTSQ CSCSSTIVHV PPPEPAEDAA LGCEPWTLNT
QPAPFTAEEF KHVGLTTASL SAHTQREEQD YVDRFRKKIL SSPYSCCLHR ESSSKARRSC
VQGDFTSKQS RLAGCRKGKH KRTKPPVPLG SSSSSDSFHS QAGGPLQDVL PWCPSTPSSA
CASGLGFPAA VMVPSQSSYL LPAFPLPAWA ATPECPPKPP VSSGLQHLPA LPSLHVDTLM
TFFLHNPRIC PLWSPSFSPY PFLGATDSSE ILPSVSAVAP NLEPPPSVNS GRVEENWEMQ
KEEHLFISSR SSSPLQLDLL HEDMPASPEP PDAVRRDAGP EATDHCVSGG GGSRSSSAAG
DLSPAPPHKV SPSGAGSAAS GSSSSCIFFT STDYSSESSE NGQQSQDTQK TSAFHSLAED
PIWKMIAQTP ECVLMTYQVP ERVKEVVLKE DLEKLESLRQ QQPQFSPGQK EELAKVHPWI
QSQTVPGGMH VQSCATCEDG GSAGDTAEAP GRIQEKTAAE PP
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