ID I3MMG9_ICTTR Unreviewed; 715 AA.
AC I3MMG9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSSTOP00000012730.3};
GN Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSSTOP00000012730.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012730.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000012730.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01051199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01051208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MMG9; -.
DR Ensembl; ENSSTOT00000014211.3; ENSSTOP00000012730.3; ENSSTOG00000014200.3.
DR GeneTree; ENSGT00940000160935; -.
DR HOGENOM; CLU_1113566_0_0_1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 229..445
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 78676 MW; D17F04F25CC76BDC CRC64;
RLVGLRPQKQ ELANSSDVTL PDRPLSPPLT APPTMKSAEF FEMLEKMQGI KLEEQKPGPQ
KNKDDYIPYP SIDEVVEKGG PYPLIILPQF GGYWIEDPEN VGTPTSLGSS ICEEEEEDNL
SPNTFGYKLE CKGEARAYRR HFLGKDHLNF YCTGSSLGNL ILSIKCEEVE GIEYLRIILR
SKLKTVHERI PLAGLSKLPS VPQIAKAFCD DAVGLKFNPV LYPKASQMIV SYDEHDVNNT
FKFGVIYQKA RQTLEEELFG NNEESPAFKE FLDLLGDTIT LQDFKGFRGG LDVTHGQTGV
ESVYTTFRDR EIMFHVSTKL PFTEGDAQQL QRKRHIGNDI VAIIFQEENT PFVPDMIASN
FLHAYIVVQV ESPGTETPSY KVSVTAREDV PAFGPPLPSP PVFQKGPEFR EFLLTKLTNA
ENACCKSDKF AKLEDRTRAA LLDNLHDELH AHTQVMLGLG PEEDKFENGG HGGFLESFKR
AIRVRSHSME TMVGSQRKLH SGGIPGSLSG GIVHNSMEVT KTTFSPPAAA ATVKNQSRSP
IKRRSGLFPR LHTGSEGQGD GRTRCDSASS TPKTPDGGHS SQEIKSETSS NPSSPEICPN
KEKPFIKLKE NGRANISRSS SSTSSFSSTA GEGEAMEECD SGSSQPSTTS PFKQEVFVYS
PSASSENPSL GAAATPIIMS RSPTDGKSRN SPRSNLKFRF DKLSHASSSA VRIWV
//
