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Database: UniProt
Entry: I3MMV2_ICTTR
LinkDB: I3MMV2_ICTTR
Original site: I3MMV2_ICTTR 
ID   I3MMV2_ICTTR            Unreviewed;       499 AA.
AC   I3MMV2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   18-SEP-2019, entry version 45.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000012898};
GN   Name=KCNJ3 {ECO:0000313|Ensembl:ENSSTOP00000012898};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000012898, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000012898}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000012898}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AGTP01000397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005315848.1; XM_005315791.2.
DR   STRING; 43179.ENSSTOP00000012898; -.
DR   Ensembl; ENSSTOT00000014399; ENSSTOP00000012898; ENSSTOG00000014395.
DR   GeneID; 101966839; -.
DR   CTD; 3760; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193368; -.
DR   InParanoid; I3MMV2; -.
DR   OrthoDB; 956263at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0099056; C:integral component of presynaptic membrane; IEA:Ensembl.
DR   GO; GO:0098688; C:parallel fiber to Purkinje cell synapse; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003274; K_chnl_inward-rec_Kir3.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01327; KIR31CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   DOMAIN       45    185       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      192    362       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION        1     38       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS     12     29       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   499 AA;  56355 MW;  DF79E9431102F6D0 CRC64;
     MSAIRRKFGD DYQVVTTSSS GSGLQPHGPG PQQQLVPKKK RQRFVDKNGR CNVQHGNLGS
     ETSRYLSDLF TTLVDLKWRW NLFIFILTYT VAWLFMASMW WVIAYTRGDL NKAHVGNYTP
     CVANVYNFPS AFLFFIETEA TIGYGYRYIT DKCPEGIILF LFQSILGSIV DAFLIGCMFI
     KMSQPKKRAE TLMFSEHAVI SMRDGKLTLM FRVGNLRNSH MVSAQIRCKL LKSRQTPEGE
     FLPLDQLELD VGFSTGADQL FLVSPLTICH VIDAKSPFYD LSQRSMQTEQ FEIVVILEGI
     VETTGMTCQA RTSYTEDEVL WGHRFFPVIS LEEGFFKVDY SQFHATFEVP TPPYSVKEQE
     EMLLMSSPLI APAITNSKER HNSVECLDGL DDISTKLPSK LQKITGREDF PKKLLRMSST
     TSEKAYSLGD LPMKLQRISS VPGNSEEKLV SKTTKMLSDP MSQSVADLPP KLQKMAGGAA
     RMEGNLPAKL RKMNSDRFT
//
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