ID I3MPL4_ICTTR Unreviewed; 2098 AA.
AC I3MPL4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Myosin VIIB {ECO:0000313|Ensembl:ENSSTOP00000013756.3};
GN Name=MYO7B {ECO:0000313|Ensembl:ENSSTOP00000013756.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013756.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013756.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AGTP01000749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000013756; -.
DR Ensembl; ENSSTOT00000015359.3; ENSSTOP00000013756.3; ENSSTOG00000015334.3.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000157247; -.
DR HOGENOM; CLU_000192_14_1_1; -.
DR InParanoid; I3MPL4; -.
DR TreeFam; TF335306; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0090651; C:apical cytoplasm; IEA:Ensembl.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 66..666
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 969..1171
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1176..1485
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1480..1546
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1623..1775
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1781..2084
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 638..660
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2098 AA; 239654 MW; EBCAF29F5D9AA4D9 CRC64;
FHIFRILGDH VWLEPASTNK TEVAIGGIIK ETKPGKVLVE DDEGKEHWIQ AEDFGVLSPM
HPNSVEGVDD MIRLGDLNEA GMVHNLLIRY QQHKIYTYTG SILVAVNPFQ MLPLYTLEQV
QLYYGRHVGE LPPHVFAIAN SCYFSMKKNK KDQCCVISGE SGAGKTETTK LILQFLATIS
GQHSWIEQQV LEANPILEAF GNAKTIRNDN SSRFGKYIDI YFNTSGVIEG ARIEQFLLEK
SRVCRQAAEE RNYHIFYCML MGMSVEEKKL LGLGMPSEYH YLTMGNCTSY EGLNDAKDYA
HVRSAMKILL FSDSENWDIS KLLAAILHLG NVEFMAAVFE NLDSSDVMET PAFPIMMNLL
EVQYQALRDC LIKHTILIRG EYVTRPLNIA QAADRRDAFV KGIYGHLFLW IVKKINAAIF
PPPAQDPKNV RRAIGLLDIF GFENFQNNSF EQLCINFANE HLQQFFVQHV FTMEQEEYRS
ENISWDYIHY TDNRPTLDLL ALKPMSVISL LDEESRLPQG TDITMLQKLN SVHANNKAFL
KPKNIHDARF GIAHFAGEVY YQAEGFLEKN RDMLSADILT LVYSSKNKFL REIFNLESAE
TKLGHGTIRQ AKTRNQFFKG TDSTKRPSTL ASQFKQSLDQ LMKILTNCQP YFIRCIKPNE
YKKPLVSRNL EHPNILPMVS VPNGTEPPPV FPVQLQDKFR QMTLCITEVC LGTDKEWRVG
KTKIFLKDHQ DTLLEIQRSQ ALDEAAIRIQ RVMRGYKYRK EFLRQRRAAV TLQAEWRGYC
SRKNFKLILV GFERLQAIAR SHLLMRQFQA TRQRMVQLQA RCRGYLVRQQ IQAKRRAIVT
IQAHARGMAA RRSFQRRKAK GPLVIPVKEQ ESENVLPSKK RKSIYDTVTD TEMVEKVFGF
LPSMIGGQEG QAPTGFEDLE VKTQKKLPEI DLDTVPMLKE PEEDVDGLAE YTFPKFAVTY
FQKSATHTHI QRPLRYPLLY HEDDTDYSAA LAVWNIILRF MGDLPEPMLY AKNSLSGSPV
MQQIHNTLDK ENGPRGLQHG SAQVASQLNI GEEPFDLDGP ISERPMSNLE KVHFIVGYAI
LRPGLRDEIY CQICKQLSGN SRKSSTARGW ILLSLCLGCF PPSERFMKYL LNFIGQGPAG
YGPFCAERLR RTYANGVRAE PPTWLELQAV KSKKHIPIQV ILVTGESLAV MVDSASTSRE
ICQHIAQKKG LRDYLGFSLQ VAVYDKFWSL GSGRDHVMDA VAQCEQLAQE KGASQRQSPW
RIYFRKEFFT PWHDSQEDPV STELIYRQVL HGVWSGEYSF EKEEELVELL ARHCYVQLGA
SLRGRAVQEL LPGCVPSKLY KTKPPEKWAS LVTDAHTKAP YTQTRATTLA VQEQVVDTAL
LQWPLLFSRL FEVTTLSGPR LPKTQLILAV NWKGLYFLDQ RERKLLELSF PEIMGLVTNR
EAKGGQRLLL STLHEEYEFV SPSCVAIAEL VALFLEGLKE RSVFAMALQD RKATDDVTLL
PFKKGDLIIL TKKQALLVSE SWTLGQNDRT GKTGLVPTAC LYTIPTLSKP SSQLLSLLAM
SPEKRKLAAQ EKQSSEPLPE EQPKEKLHTL EDFSYEFFRT PEKETVSRAM MPLARTRGHL
WAYSLEPLRQ PLLKRVHDRA DLRDAACQIF QDILPQPPYM GDYPSRQAWP TLELTDQIFS
LPLQDSALQD EVYCQILKQL TQNSNRYSEE RGWQLLWLCT GLFPPGKALL PHAQKFLDTR
RKKLLAPDCS RHIQKVLRTG PRKQPPHQVE VEAAEQNVSR LCHKIYFPND TNEMLEVGAN
TRVRDVCESI ATRLQLASWE GCSLFIKISD KVISQKEGDF FFDSLRHMSD WVKKNKPQKE
GAPVTLPYQV YFMRKLWINV APGKDVNADT ILHYHQELPK YLRGFHKCSR EDAVHLAGLI
YKAQFDNDRS QLASIPKILR ELVPENLTRL MSSEEWKKSL LVECDKHKDK TVQEAKVAFL
KWICRWPTFG SAFFEVKQTS EPSYPDIVLI AINRHGVLLI HPKTKDLLTT YPFTKISNWS
SGSTYFHMAL GSLGRGTRLL CETSLGYKMD DLLTSYVQQL LSAVNKQRGP RAPSLAST
//
