ID I3MPP1_ICTTR Unreviewed; 545 AA.
AC I3MPP1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=PX domain containing serine/threonine kinase like {ECO:0000313|Ensembl:ENSSTOP00000013792.2};
GN Name=PXK {ECO:0000313|Ensembl:ENSSTOP00000013792.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013792.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013792.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01005562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01005563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MPP1; -.
DR STRING; 43179.ENSSTOP00000013792; -.
DR Ensembl; ENSSTOT00000015401.3; ENSSTOP00000013792.2; ENSSTOG00000015398.3.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00390000017669; -.
DR HOGENOM; CLU_036868_0_0_1; -.
DR InParanoid; I3MPP1; -.
DR OMA; FTQYAST; -.
DR TreeFam; TF324116; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:Ensembl.
DR CDD; cd06871; PX_MONaKA; 1.
DR CDD; cd22062; WH2_DdVASP-like; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR037903; MONaKA_PX.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR22999:SF40; PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22999; PX SERINE/THREONINE KINASE PXK; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 1..92
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 54..448
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 515..534
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 403..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..498
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 61446 MW; 67D1DBA5D8394726 CRC64;
EYIIRVQRGI SAENSWQIVR RYSDFDLLNN SLQIAGLSLP LPPKKLIGNM DREFIAERQK
GLQNYLNVIT TNHILSNCEL VKKFLDPNNY SANYTEIALQ QVSMFFRSEP KWEVVEPLKD
IGWRIRKKYF LMKIKNQPKE RLVLSWADLG PDKYLSDKDF QCLIKLLPSC LHPYIYRVIF
ATANESSALL IRTFNEKGTL KDLIYKAKPK DPFLKKYCNP KKIQGLELQQ IKTYGRQILE
VLKFLHDKGF PYGHLHASNV MLDGDTCRLL DLENSLLGLP SFYRSYFTQF RKINTLESVD
VHCFGHLLYE MTYGRPPDSV PVDSFPPAPS MAVVAVLEST LSCDACKNGM PAVSRLLQMP
LFSDVLLTTS EKPQFKIPTK LKEALRIAKE CIEKRLIEEQ KQIHQHRRLT RAQSHHGSEE
ERKKRKILAR KKSKRSAIEN SEEYSAKYSN SNNSAGSGAS SPLTSPSSPT PPSTAGLSAL
PPPPPPPPPP PAAPLPPAST EMPAQLSSQA VNGVSRGALL SSIQNFQKGT LRKTETCDHS
APKIG
//
