GenomeNet

Database: UniProt
Entry: I3MPR5_ICTTR
LinkDB: I3MPR5_ICTTR
Original site: I3MPR5_ICTTR 
ID   I3MPR5_ICTTR            Unreviewed;      2668 AA.
AC   I3MPR5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSSTOP00000013829};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSSTOP00000013829};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013829, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000013829}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000013829}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AGTP01054777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01054786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000013829; -.
DR   Ensembl; ENSSTOT00000015442; ENSSTOP00000013829; ENSSTOG00000015423.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; I3MPR5; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2195   2217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2229   2248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2269   2293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2313   2341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2362   2384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2489   2512       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    254       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      261    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   COILED     1563   1583       {ECO:0000256|SAM:Coils}.
FT   COILED     1889   1909       {ECO:0000256|SAM:Coils}.
FT   COILED     2599   2647       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2668 AA;  304305 MW;  379271BA363AD081 CRC64;
     MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV
     CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENKKL LGEIVKYSNV
     IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNVNAVN
     CNTSWKITLF MKFSSYREDV LKGGDVVRLF HAEQEKFLTC DEYEKKQHIF LRTTLRQSAT
     SATSSKALWE IEVVHHDPCR GGAGQWNSLF RFKHLATGNY LAAELNPDYR DAQNEGKNVR
     DGDLPTSKKK RQSGEKIMYT LVSVPHGNDI ASLFELDATT LQRADCLVPR NSYVRLRHLC
     TNTWVTSTSI PIDTDEERPV MLKIGTCQTK EDKEAFAIVS VPLSEVRDLD FANDANKVLA
     TTVKKLENGT ITQNERRFVT KLLEDLIFFV ADVPNNGQEV LDVVITKPNR ERQKLMREQN
     ILAQVFGILK APFKEKAGEG PMLRLEDLGD QRYAPYKYML RLCYRVLRHS QQDYRKNQEY
     IAKNFCVMQS QIGYDILAED TITALLHNNR KLLEKHITAK EIETFVSLLR RNREPRFLDY
     LSDLCVSNTT AIPVTQELIC KFMLSPGNAD ILIQTKLVSM QVDNPLESCI LPDDLDDEEV
     WLYWIDSNKE PHGKAIRHLA QEAKEGTKAD LEVLTYYRYQ LNLFARMCLD RQYLAINQIS
     TQLSVDLILR CVSDESLPFD LRASFCRLML HMHVDRDPQE SVVPVRYARL WTEIPTKITI
     HEYDSITDSS RNDMKRKFAL TMEFVEEYLK EVVNQPFPFG DKEKNKLTFE VVHLARNLIY
     FGFYSFSELL RLTRTLLAIL DIVQAPMSSY FERLSKFQDG GNNVMRTIHG VGEMMTQMVL
     SRGSIFPVSV PDVQPSIHPT KQVSPTEHED VTVMDTKLKI IEILQFILSV RLDYRISYML
     SIYKKEFGEN NENAETSANG SPDTLLPSAI VPDIDEIAAQ AETMFAGRKE KNPVQLDDEG
     GRTFLRVLIH LIMHDYAPLL SGALQLLFKH FSQRAEVLQA FKQVQLLVSN QDVDNYKQIK
     ADLDQLRLTV EKSELWVEKS GSYENGEIGE SQVKGGEEPN EESNILSPVQ DGTKKPQIDS
     NKSNNYRIVK EILIRLSKLC VQNKKCRNQH QRLLKNMGAH SVVLDLLQIP YEKNDEKMNE
     VMNLAHIFLQ NFCRGNPQNQ ILLHKHLNLF LTPGLLEAET MRHIFMNNYH LCNEISERVV
     QHFVHCIETH GRHVEYLRFL QTIVKADGKY VKKCQDMVMT ELINGGEDVL IFYNDRASFP
     ILLHMMCSER DRGDDSGPLA YHITLVELLA ACTEGKNVYT EIKCNSLLPL DDIVRVVTHD
     DCIPEVKIAY VNFVNHCYVD TEVEMKEIYT SNHIWKLFEN FLVDMARVCN STTDRKHADV
     FLEKCITESV MSIVSGFFSS PFSDNSTSLQ THQPVFIQLL QSAFRIYNCT WPNPAQKASV
     ESCIRTLAEV AKNRGIAIPV DLDSQVNTLF MKSHSNMVQR AAMGWRLSAR SGPRFKEALG
     GPAWDYRNII EKLQDVVASL EQQFSPMTQA EFSVLVDVLY SPELLFPEGS DARIRCGTFM
     SKLINHTKKL MEKEEKLCIK ILQTLREMLE KRDSFVEEGS ILRKILLNRY FKGDYGVGMN
     GHLTGNYAKI AQVGGSFSGQ DSDKTGISMS DIQSLLDKEG ASELVIDVIV NTKNDRIFSE
     GILLGIALLE GGNSQTQSSF YKQLHEQKKS EKFFKVLYDR MKAAQKEIRS TVTVNTIDLG
     SKKRDEDSEL MTSGPRVRVR DSSLHLKEGM KGQLTEASSA TSKAYCVYRR EMDPEIDIMC
     TGSEVGNVEE KSAEEVTMSP AIAIMQPILR FLQLLCENHN RELQNFLRNQ NNKTNYNLVC
     ETLQFLDCIC GSTTGGLGLL GLYINEKNVA LVNQTLESLT EYCQGPCHEN QTCIATHESN
     GIDIIIALIL NDINPLGKYR MDLVLQLKNN ASKLLLAIME SRHDSENAER ILFNMRPREL
     VDVMKNAYNQ GLECDHGEDE GGDDGVSPKD VGHNIYILAH QLARHNKLLQ QMLKPGSDPD
     EGDEALKYYA NHTAQIEIVR HDRTMEQIVF PVPNICEFLT RESKCRVFNT TERDEQGSKV
     NDFFQQTEDL YNEMKWQKKI RNNPALFWFS RHISLWGSIS FNLAVFINLA VALFYPFGDD
     GDEGTLSPLF SVLLWIAVAI CTSMLFFFSK PVGIRPFLVS VMLRSIYTIG LGPTLILLGA
     ANLCNKIVFL VSFVGNRGTF TRGYGAVILD VAFLYHVAYV LVCMLGLFVH EFFYSFLLFD
     LVYREETLLN VIKSVTRNGR SIILTAVLAL ILVYLFSIIG FLFLKDDFTM EVHRLKNRTP
     VTGNYGVPTM TLPSMMEACE KENCSPTIPS SNTADEEYED GIERTCDTLL MCIVTVLNQG
     LRNGGGVGDV LRKPSKDEPL FAARVVYDLL FFFIVIIIVL NLIFGVIIDT FADLRSEKQK
     KEEILKTTCF ICGLERDKFD NKTVSFEEHI KSEHNMWHYL YFIVLVKVKD PTEYTGPESY
     VAQMIVEKNL DWFPRMRAMS LVSNEGDSEQ NEIRNLQEKL ESTMSLVKQL SGQLAELKEQ
     MTEQRKNKQR LGFLGSNTPH VNHHMPPH
//
DBGET integrated database retrieval system