ID I3MQ13_ICTTR Unreviewed; 1337 AA.
AC I3MQ13;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Roundabout guidance receptor 2 {ECO:0000313|Ensembl:ENSSTOP00000013970.3};
GN Name=ROBO2 {ECO:0000313|Ensembl:ENSSTOP00000013970.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000013970.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000013970.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01033513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01033522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000015607.3; ENSSTOP00000013970.3; ENSSTOG00000015604.3.
DR GeneTree; ENSGT00940000156324; -.
DR HOGENOM; CLU_003227_5_1_1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF52; ROUNDABOUT HOMOLOG 2; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1337
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012226608"
FT TRANSMEM 819..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..309
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 314..409
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 417..504
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 524..618
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 698..795
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 993..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1186
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1283..1300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1322..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1337 AA; 146509 MW; 12DCC24662B9C303 CRC64;
MSLLMFTQLL LCGFLYVLVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP
TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV
SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEDR
ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE
AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKALSTDEGT YMCIAENRVG
KVEASATLTV RAPPQFVVRP RDQIVAQGRT ATFPCETKGN PQPAVFWQKE GSQNLLFPNQ
PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII
LQGPVNQTLA VDGTALLKCK ATGDPLPVIS WLKEGFTFLG RDSRASIQEQ GTLQIKNLRI
SDTGTYTCVA TSSSGETSWS AVLDVTESGA TISKNYDLND LPGPPSKPQV TDVTKNSVTL
SWQPGTPGTL PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP
QGLSDPSPMS DPVRTQVDRQ PQFIQGYRVM YRQTSGLQAT SSWQNLDAKV PTERSAVLVN
LKKGVTYEIK VRPYFNEFQG MDSESKTVRT TEEAPSAPPQ SVTVLTVGSH NSTSISVSWD
PPPPDHQNGI IQEYKIWCLG NETRFHINKT VDAAIRSVII GGLFPGIQYR VEVAASTSAG
VGVKSEPQPI IIGGRNEVVI TENNNSITEQ ITDVVKQPAF IAGIGGACWV ILMGFSIWLY
WRRKKRKGLS NYAVTFQRGD GGLMSNGSRP GLLNAGDPSY PWLADSWPAT SLPVNNSNSG
PNEIGNFGRG DVLPPVPGQG DKTATMLSDG AIYSSIDFTT KTTYNSSSQI TQATPYATTQ
ILHSNSIHEL AVDLPDPQWK SSIQQKTDLM GFGYSLPEQN KGNNGGKGGK KKKNKNSSKP
QKNNGSTWAN VPLPPPPVQP LPGTELEHYA VEQQENGYDS DSWCPPLPVQ TYLHQGMEDE
LEEDDDRVPT PPVRGVASSP AISFGQQSTA TLTPSPREEM QPMLQAHLDE LTRAYQFDIA
KQTWHIQSNN PPPQPPIPPL GYVSGALISD LETDVPDDDA DDEEEALEIP RPLRALDQTP
GSSMDNLDSS VTGKSFTSSQ RPRPTSPFST DSNTSAALNQ SQRPRPTKKH KGGRMDQQPA
LPHRREGMTD EEALVPYSKP SFPSPGGHSS SGTASSKGST GPRKPEVLRG GHQRNASDLL
DIGYMGSNSQ GQFTGEL
//
