ID I3MQ87_ICTTR Unreviewed; 855 AA.
AC I3MQ87;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=TATA-box binding protein associated factor 4b {ECO:0000313|Ensembl:ENSSTOP00000014071.3};
GN Name=TAF4B {ECO:0000313|Ensembl:ENSSTOP00000014071.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014071.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000014071.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF4 family.
CC {ECO:0000256|ARBA:ARBA00006178}.
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DR EMBL; AGTP01055633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01055638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MQ87; -.
DR Ensembl; ENSSTOT00000015719.3; ENSSTOP00000014071.3; ENSSTOG00000015714.3.
DR GeneTree; ENSGT00390000011620; -.
DR HOGENOM; CLU_030501_0_0_1; -.
DR TreeFam; TF316520; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd08045; TAF4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.20.120.1110; TAFH/NHR1 domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR045144; TAF4.
DR InterPro; IPR007900; TAF4_C.
DR InterPro; IPR037249; TAFH/NHR1_dom_sf.
DR InterPro; IPR003894; TAFH_NHR1.
DR PANTHER; PTHR15138; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4; 1.
DR PANTHER; PTHR15138:SF17; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4B; 1.
DR Pfam; PF05236; TAF4; 1.
DR Pfam; PF07531; TAFH; 1.
DR SMART; SM00549; TAFH; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF158553; TAFH domain-like; 1.
DR PROSITE; PS51119; TAFH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 255..352
FT /note="TAFH"
FT /evidence="ECO:0000259|PROSITE:PS51119"
FT REGION 220..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 718..748
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 855 AA; 89994 MW; 5CF219BA511099E8 CRC64;
MPAGLSESSG AAPPVVGGAS GTVTMAPTGA LPVRVESTPV ALGAVTKAPV SVCVESTASQ
PLRSPVGTLV TKVAPVSTVP KLSGPRLPAP QIVTVKAPSA TTIQLPANLQ LPPGTVLIKS
NSGQLMLVSP QQAVPRAETT SNIAARPAAP TNAQTVKICT MPNSSSQLIK KVAVTPVKKL
AQIGTTVATT GSNPSSVQSV AVPTNVVTVT PVKPANTVST LKTSSVGSSS TPSNEPNLKA
ENSAAAQSDL SPTMLENVKK CKNFLAMLIK LACSGSQSPE MGQNVKKLVE QLLDAKIEAE
EFTRKLYVEL KSSPQPHLVP FLKKSVTALR QLLPNSQSFI QQCVQQTSGE VVITTCTSTA
TPPVATTTVS SPIIVSGTTT SRTVSVQALN PLAGPGGAKT GVVTLHSVGP ASVPGGTTAG
TVLLQTSKPL VTSVPNTVTN VSLQPEKPVV SGAAVTLALP SVTFGETSAA ALCIPSVKPV
ISSAGTTPDK PVIGTPVQIK LAQPGPLLSQ PAGVPQAVKV KQLVVQQPSG GIAKQVTTIS
HSPALTIQKS GQNKMPVNTV IPASKFLPAS ILKQITLPGN KILSLQASTL QKNKVKENGT
TCFRDEDDIN DVTSMAGVNL NEENACILAT NSELVGTLIQ SCKDEPFLFI GALQKRILDI
GKKHDITELN SDAVNLISHA TQERLRGLLE KLTTIAQHRM TTYKASENYI LSSDTRSQLK
FLEKLDQLEK QRKDLEEREM LLKAAKSRSN KEDPEQLRLK QKAKELQQLE LAQIQHRDAN
LTALAAIGPR KKRPLESGSE GLKDNFLASG ASSLTATKQL LRPRITRVCL RDLIFCMEQE
REMKYSRALY LALLK
//
