ID I3MQB1_ICTTR Unreviewed; 888 AA.
AC I3MQB1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 {ECO:0000313|Ensembl:ENSSTOP00000014104.3};
GN Name=HERC6 {ECO:0000313|Ensembl:ENSSTOP00000014104.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014104.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000014104.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR EMBL; AGTP01093902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01093909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MQB1; -.
DR STRING; 43179.ENSSTOP00000014104; -.
DR Ensembl; ENSSTOT00000015759.3; ENSSTOP00000014104.3; ENSSTOG00000015762.3.
DR GeneTree; ENSGT00940000162279; -.
DR HOGENOM; CLU_002173_5_3_1; -.
DR InParanoid; I3MQB1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF11; E3 UBIQUITIN-PROTEIN LIGASE HERC6-RELATED; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 2.
DR Pfam; PF00415; RCC1; 5.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 2.
DR PROSITE; PS00626; RCC1_2; 4.
DR PROSITE; PS50012; RCC1_3; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 38..89
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 90..142
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 143..195
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 196..250
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 244..295
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 668..774
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT DOMAIN 819..888
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 858
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 888 AA; 98923 MW; D4F4F97B5FD03620 CRC64;
MYFSWGAGSQ GRKRGARGDQ LLQAASGERH SLLLLNHHEV HSFGDNSRGQ LGQRGVPRRE
RPELIQALAT LHVAFVSCGK EHSLAVCHRG RVFAWGAGSE GQLGIGEIKE INFIPKKINA
LADIKIIQVS CGHYHSLALS KDGQVFSWGK NSHGQLGLGN EFPSQASPQR VKSLEGIPLA
QVAAGGAHSF ALSLCGTSFG WGNNNAGQLA LSGKNVPEQS YKPRSIGALK NLGVIYISCG
DEHTAVLTQV IQNVRGQLGH STTAKSRGPQ LVKRINGLVS QIDCGSYHTL AYVYTTGQVV
SFGHGPGCTS NPAHSEATTE DFDMRCLISA SGMNFTGTIS SITTTRKHDA SSTSVSKKIL
PEISRMNQSL AEKWLAVKIG SSEYEVAKSE IGIIFSSPAC LTASFLKQRG TEERISIDVD
LQMARDIFKK ITKKEWISSM MTTSLRDNLL QALPYHSPHQ EALSVFLLLP ECPVMQDSQN
QSLVVSFAEA VCKMSNQSLQ VLRKCWALSE ASSLNTLVQM LKTPIASQLR FPRLLMIVEQ
NHLNFKALLG TMKEVHKKNK SNCQLPEDTF HINELSDLLD FREERRKLFA ECNSLVNTPS
PIPFSDFPFI FNLPCKIKLL KADAEIKRMS VFPSLSPSNG LFTLRVRRTH LVEDALRQLC
QAEVPDLRKL FVEFIEEIRP ENGGVSSEFF HCMFEEMTKP NYGMFMYPEK NSYMWFPVNP
TIEKKNYFLF GILCGLSLYN LNVANLSFPL ALYKKLLCKK PSLEDLKELR KNWYCGVVDY
SDLQSCLIHW DQTDVDLIPN GISVPVDQSN NTLTKLHSFL VFLTGRDRLH VRGIQDVGIQ
FRCPTTCSEN DFPRSLTCHS ILYLPKYSTM ERMQEALQVA INNSRGFV
//
