ID   I3MQC5_ICTTR            Unreviewed;       387 AA.
AC   I3MQC5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014122.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000014122.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR   EMBL; AGTP01093916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01093917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3MQC5; -.
DR   STRING; 43179.ENSSTOP00000014122; -.
DR   Ensembl; ENSSTOT00000015781.3; ENSSTOP00000014122.3; ENSSTOG00000032414.1.
DR   eggNOG; KOG0941; Eukaryota.
DR   GeneTree; ENSGT00940000162703; -.
DR   InParanoid; I3MQC5; -.
DR   TreeFam; TF315189; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          157..379
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
SQ   SEQUENCE   387 AA;  45910 MW;  DD91D7595B07CC29 CRC64;
     MFMKAINSQL HYWTENNENN CHLKALLEIL KKLHRVNQIK YQLPEDIFKL DVLSDWLNFY
     GEAYRRSCWK MNLDTSEDMH CVIFSHFPFV FDIRSKTKLL YADSILKIQE RKIRAYVSLA
     GIIEQEESEL ASLSTFNLRV RRNHLIEDVL SQLSQFENED LRRELRVSFI GEIGYEYDLG
     GVKTEFFYCL FEEMTRPEYG MFIYPEEASY MWFPARPKFE EKRYFFFGVL CGLSLFNRSV
     ANIPFPLALF KKLLDQVPSL EDLKELSPVL AKSLQTLLDD EGNDFGEVFY VHFNLHWDRN
     DENLIPNGSS IVVNQTNKRD YVSKCVDYIF NISVKTVYKE FQRGFYKVCD KEIIEIFHPE
     ELKDVIVGNT DYDWETLEKV HRGCQIN
//