ID I3MQE4_ICTTR Unreviewed; 232 AA.
AC I3MQE4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Protein lin-7 homolog {ECO:0000256|PIRNR:PIRNR038039};
GN Name=LIN7A {ECO:0000313|Ensembl:ENSSTOP00000014150.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014150.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000014150.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. {ECO:0000256|PIRNR:PIRNR038039}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004171}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004171}. Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|PIRNR:PIRNR038039}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00023767}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00023767}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034098}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00034098}.
CC -!- SIMILARITY: Belongs to the lin-7 family.
CC {ECO:0000256|ARBA:ARBA00008546, ECO:0000256|PIRNR:PIRNR038039}.
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DR EMBL; AGTP01095801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005338053.1; XM_005337996.1.
DR AlphaFoldDB; I3MQE4; -.
DR STRING; 43179.ENSSTOP00000014150; -.
DR Ensembl; ENSSTOT00000015810.3; ENSSTOP00000014150.2; ENSSTOG00000015812.3.
DR GeneID; 101976862; -.
DR CTD; 8825; -.
DR eggNOG; KOG3550; Eukaryota.
DR GeneTree; ENSGT00940000153222; -.
DR HOGENOM; CLU_097962_0_0_1; -.
DR InParanoid; I3MQE4; -.
DR OMA; EHETEFI; -.
DR OrthoDB; 4175920at2759; -.
DR TreeFam; TF316850; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-UniRule.
DR GO; GO:0097016; F:L27 domain binding; IEA:Ensembl.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-UniRule.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14063; PROTEIN LIN-7 HOMOLOG; 1.
DR PANTHER; PTHR14063:SF4; PROTEIN LIN-7 HOMOLOG A; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 2.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038039};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038039};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|PIRNR:PIRNR038039};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038039};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR038039};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038039}.
FT DOMAIN 25..80
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 108..190
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT COILED 193..229
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 232 AA; 25885 MW; 4D4167563F5B97DF CRC64;
MLKLSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL QSLKKVLQSE
FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS EGHSHPRVVE LPKTDEGLGF
NVMGGKEQNS PIYISRIIPG GVAERHGGLK RGDQLLSVNG VSVEGEHHEK AVELLKAAKD
SVKLVVRYTP KVLEEMEARF EKLRTARRRQ QQQLLIQQQQ QQQQQTQQNH MS
//
