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Database: UniProt
Entry: I3MR03_ICTTR
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Original site: I3MR03_ICTTR 
ID   I3MR03_ICTTR            Unreviewed;       424 AA.
AC   I3MR03;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   18-SEP-2019, entry version 46.
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 6 {ECO:0000313|Ensembl:ENSSTOP00000014459};
GN   Name=KCNJ6 {ECO:0000313|Ensembl:ENSSTOP00000014459};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014459, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000014459}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000014459}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AGTP01030160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSTOT00000016155; ENSSTOP00000014459; ENSSTOG00000016154.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193368; -.
DR   InParanoid; I3MR03; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     94    118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    168    192       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       58    197       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      204    373       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      389    424       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    393    424       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   424 AA;  48446 MW;  1545BCB953C67D5A CRC64;
     SAKLRTGGLA NVLEGDSMDQ DVESPVAIHQ PKLPKQARDD LPRHISRDRT KRKIQRYVRK
     DGKCNVHHGN VRETYRYLTD IFTTLVDLKW RFNLLIFVMV YTVTWLFFGM IWWLIAYIRG
     DMDHIEDPSW TPCVTNLNGF VSAFLFSIET ETTIGYGYRV ITDKCPEGII LLLIQSVLGS
     IVNAFMVGCM FVKISQPKKR AETLVFSTHA VISMRDGKLC LMFRVGDLRN SHIVEASIRA
     KLIKSKQTSE GEFIPLNQTD INVGYYTGDD RLFLVSPLII SHEINQQSPF WEISKAQLPK
     EELEIVVILE GMVEATGMTC QARSSYITSE ILWGYRFTPV LTLEDGFYEV DYNSFHETYE
     TSTPSLSAKE LAELASRAEM PLSWSVSSKL NQHAELETEE EEKNQEEQTE RNGDVANLEN
     ESKV
//
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