ID I3MRI0_ICTTR Unreviewed; 170 AA.
AC I3MRI0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=DAN domain BMP antagonist family member 5 {ECO:0000313|Ensembl:ENSSTOP00000014698.2};
GN Name=DAND5 {ECO:0000313|Ensembl:ENSSTOP00000014698.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000014698.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000014698.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR027807}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|PIRNR:PIRNR027807}.
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DR EMBL; AGTP01088443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005336278.1; XM_005336221.1.
DR AlphaFoldDB; I3MRI0; -.
DR STRING; 43179.ENSSTOP00000014698; -.
DR Ensembl; ENSSTOT00000016422.2; ENSSTOP00000014698.2; ENSSTOG00000016420.2.
DR GeneID; 101963553; -.
DR CTD; 199699; -.
DR eggNOG; ENOG502RZ3T; Eukaryota.
DR GeneTree; ENSGT00530000063926; -.
DR HOGENOM; CLU_122900_0_0_1; -.
DR InParanoid; I3MRI0; -.
DR OMA; PVVLWCR; -.
DR OrthoDB; 5347549at2759; -.
DR TreeFam; TF106445; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016015; F:morphogen activity; IEA:Ensembl.
DR GO; GO:0003283; P:atrial septum development; IEA:Ensembl.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IEA:Ensembl.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0038101; P:sequestering of nodal from receptor via nodal binding; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR PANTHER; PTHR15273:SF5; DAN DOMAIN FAMILY MEMBER 5; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR027807};
KW Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT CHAIN 24..170
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT /id="PRO_5024528261"
FT DOMAIN 64..166
FT /note="DAN"
FT /evidence="ECO:0000259|Pfam:PF03045"
SQ SEQUENCE 170 AA; 18345 MW; E2D70AF6A80DE953 CRC64;
MSRAWLTTLL GLLSAAWLPA GSGRPGPPAP PGPALALGSW KAFLGLQKPR RLGTDGLQDG
QEVTTSVSLP LDPKEVTQEM CKAVPFIQVL SRPGCTAVRV RNHLCFGRCS SLYIPGSDPT
PLVLCNSCEP TRQRWTPMVL WCRPGSPASS RRRVKVSTRL VEGCRCGPKL
//
