ID I3MST9_ICTTR Unreviewed; 456 AA.
AC I3MST9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ribonuclease inhibitor {ECO:0000256|ARBA:ARBA00014554};
DE AltName: Full=Ribonuclease/angiogenin inhibitor 1 {ECO:0000256|ARBA:ARBA00032534};
GN Name=RNH1 {ECO:0000313|Ensembl:ENSSTOP00000015184.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015184.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000015184.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.
CC May play a role in redox homeostasis. {ECO:0000256|ARBA:ARBA00025561}.
CC -!- SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
CC {ECO:0000256|ARBA:ARBA00011699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AGTP01115374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005341673.1; XM_005341616.2.
DR RefSeq; XP_013221300.1; XM_013365846.1.
DR RefSeq; XP_013221301.1; XM_013365847.1.
DR AlphaFoldDB; I3MST9; -.
DR STRING; 43179.ENSSTOP00000015184; -.
DR Ensembl; ENSSTOT00000024908.2; ENSSTOP00000015184.2; ENSSTOG00000020767.2.
DR GeneID; 101959690; -.
DR CTD; 6050; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000161492; -.
DR HOGENOM; CLU_002274_4_6_1; -.
DR InParanoid; I3MST9; -.
DR OrthoDB; 55870at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0032311; C:angiogenin-PRI complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008428; F:ribonuclease inhibitor activity; IEA:Ensembl.
DR GO; GO:0045765; P:regulation of angiogenesis; IEA:Ensembl.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041302; LRR_RI_cap.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 7.
DR Pfam; PF18779; LRR_RI_capping; 1.
DR SMART; SM00368; LRR_RI; 13.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
SQ SEQUENCE 456 AA; 49801 MW; 990F63468156E401 CRC64;
MSLDIHCEQL SDARWTELLP LIQQYQVVRL DDCGLTEGRC QDISSALRVN PSLTELSLRT
NELGDAGVHL VLQGLQSPVC KIQKLSLQNC CLTEAGCGVL PGVLRSLSTL RELHLNDNPL
GDAGLRLLCE GLLDPQCHLE KLQLEYCNLT AASCEPLATV LRAKPDFKEL TVSNNDLQEA
GIQTLCQGLK DSACQLEMLK LENCGVTAAN CKALSAVVAS KASLQELDLG CNKLGDEGIA
ELCPALLRAS SRLRTLWLWE CDITAEGCKD LCRVLKAKQS LKELSLAENQ LGDEGARLLC
ESLLEPGCQL ESLWVKTCGL TAACCPYFRS VLAQNKSLLE LQISSNQLGD AGVQELCQGL
SQPGAVLRVL WLGECNVTDS GCDTLATALL VNRSLRELDL SNNCVGDPGI QRLVESLRQP
GCVLEQLVLY DIYWTEEMEE QLRTLEEHKP SLRVIS
//