ID I3MTB6_ICTTR Unreviewed; 1104 AA.
AC I3MTB6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Adhesion G protein-coupled receptor F3 {ECO:0000313|Ensembl:ENSSTOP00000015361.2};
GN Name=ADGRF3 {ECO:0000313|Ensembl:ENSSTOP00000015361.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015361.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000015361.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01025128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MTB6; -.
DR STRING; 43179.ENSSTOP00000015361; -.
DR Ensembl; ENSSTOT00000027356.2; ENSSTOP00000015361.2; ENSSTOG00000001610.3.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161541; -.
DR InParanoid; I3MTB6; -.
DR TreeFam; TF316380; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15253; 7tmB2_GPR113; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR45813:SF2; ADHESION G-PROTEIN COUPLED RECEPTOR F3; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1104
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013356892"
FT TRANSMEM 777..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 811..834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 854..878
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 410..497
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 775..1029
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1104 AA; 120346 MW; F0D6B4B4EC0D36D6 CRC64;
MACPAAPWLL LVMPLALLGS LVAPAFQPVS TTGVGTLGST CNLREEGIDK LICEKLRLRE
ELPHPWVKSY CFPLPMSTFD SHQKEELWGL FSDVSPLFQE QGQAGGESGQ QLDQEIGAGE
SVLVSAYVHL EFSDKTWPPM FSRNLTLLPA SASSSLKTLI GLSLTTECNV NHTGYSHCSC
LSGYQWNASV CSHHLLCHPQ HQSHQPCGCL VFSHPVSGYC QLLPPVTLQG SPVSCLPAVP
GNLRLNSHLQ MPGDTLNLTL RISQEATNLT WFLRRPGKPT PILLQKGTQV SLTSSQGQVV
LSISHMSQYW AGEYMSCFEA QGFRWELRQV VKVPLQQKEV ARIPEKLSIS CATSSGFQLS
CCIPRTHLAY TAAWNPEEGS QASASLLTTS GSQCLVLAIQ RCPAADTTYT CVLQSQDLDP
LRFPVPVTII QDGDTTCPEN FSVVAWNVTK AGHVAEAPCP MNKMGVVKRP CRPDGIWGPV
QTDCTDVGIL ALCIKAKLLQ AGQGRPAEEV PQILAQLQRR VGMASSPSDL VALLSTVKSL
SEVVAEDRMH LDRSALEDLL ATTDNILDMN ISSLWTQAQV QKPTEGSHFL LAVETLVRSL
SPEDQPFSFN SSNVLLQSQF FEPTLPQYRI SFPTQPPVWA EIPSHSLAPL VHNGTNISVT
SLVLQKLDHL LPSNYGQGLG DSFYATDGLV LVISIMAGGQ AFTQAEVIMD FGDTDDFLHC
VFWDHKLFGG EGGWSGEGCR ADAAIASPAT WCICQHLTAF SILMSRQTVP ENPVLDLLSQ
VGLGSSILAL LVCLGVYRLV WRVVVRNKVA FFRHAALLNM VICLLAADTI FLGASFLPPG
YLTPLCLATT FLTHFFYLAT FFWMLAQALV LAHQLLFVFH QLSKHRVLSL MVILGYLCPL
VFASVTLGLY LPQGQYLREG KCWLDGKGGA FYTFVGPLLA IVGVNGLVLA TAVLKLLRPS
LSEGPPVEKR QALLGVIKAL LILTPIFGLT WGLGLATLLE EVSTVPHYIF TALNSFQGVF
ILLFGCLTDK KVQEALRKRF CSNQPPNSTI SLVSCSIQSH SLPKGDGHSW QQGEDWGWLL
ERASFKTGTL AHACNPSGMW DAEA
//
