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Database: UniProt
Entry: I3MTR1_ICTTR
LinkDB: I3MTR1_ICTTR
Original site: I3MTR1_ICTTR 
ID   I3MTR1_ICTTR            Unreviewed;      1696 AA.
AC   I3MTR1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   05-JUN-2019, entry version 56.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSTOP00000015506};
GN   Name=ARAP2 {ECO:0000313|Ensembl:ENSSTOP00000015506};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015506, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000015506}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000015506}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
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DR   EMBL; AGTP01015471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01015472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01015473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000007397; -.
DR   Ensembl; ENSSTOT00000023653; ENSSTOP00000015506; ENSSTOG00000019405.
DR   eggNOG; KOG1117; Eukaryota.
DR   eggNOG; COG5347; LUCA.
DR   GeneTree; ENSGT00940000160197; -.
DR   InParanoid; I3MTR1; -.
DR   TreeFam; TF105769; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 5.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 4.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 4.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN       10     70       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   DOMAIN      474    566       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      579    671       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      668    803       Arf-GAP. {ECO:0000259|PROSITE:PS50115}.
FT   DOMAIN      884    995       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN     1108   1289       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   DOMAIN     1318   1412       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN     1422   1525       PH. {ECO:0000259|PROSITE:PS50003}.
FT   REGION       82    102       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I3MTR1}.
FT   REGION      419    453       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I3MTR1}.
FT   REGION     1627   1661       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I3MTR1}.
FT   COILED     1561   1581       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     85     99       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                I3MTR1}.
FT   COMPBIAS    428    453       Polar. {ECO:0000256|MobiDB-lite:I3MTR1}.
FT   COMPBIAS   1627   1658       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                I3MTR1}.
SQ   SEQUENCE   1696 AA;  192959 MW;  189EC4E52880A1B9 CRC64;
     MSSVSEVNVD IKDFLMSINL EQYLLHFQEF GFYTVKDCAA INDSVLHKIG ISPTGHRRRI
     LKQLQIILSK MQEIPIYANV HKTKNGNNSK DHHHASSSDQ NTCKELSNSG CIQIPSSTQL
     ETFTKIFSME NNQSLESDVK LSLSNQDLPI PEEQHLGSSH ESLLGSENIK IESLTAKKAV
     DRTVEEQQAE KVDLISENFS NFPNTKPECL SSFDCSTSEA NSGNGANGLL ESSPPSPFFE
     FQGEMVVNDL YVPSSPVSAP MRSRSKLVSR PSRSFLLRHR PVPEIPGPAK GISGSYFRER
     RSATTLPGKS VTLQNSSEEN SSSIFPYGET FLFQRLENSK KRCIKNEFWT HEETVKGEAP
     TARNSFFIKS SIYDNKQEKL SEDKVEDIWI PREDKNNLPR DSASESEYST VEECFQSLKR
     KNSKASKSRT QKPLNSDPVN RHSYPLSSTS GNADSAVSSS AISPYACFYG SSAARVKSGW
     LDKLSPQGKR MFQKRWVKFD GLSISYYNNE REMYSKGIIP ISAVSTVRVQ GDNKFEVVTT
     QRTFVFRVEK EEERNDWISI LLNALKSQSF TSQSQAAVAP EKCGYLELRG YKAKIFTVLK
     GSNVWLCKNE QDFKSGLGIT VIPMNVANVK QVDRTVKQSF EIITPYRSFS FTAESEKEKQ
     DWIEAVQQSI AETLSDYEVA EKIWFNESNR SCADCKAPDP DWASINLCVV ICKKCAGEHR
     SLGPKDSKVR SLKMDASIWS NELIELFIII GNKRANDFWA GNLQKDEELH MDSPVEKRKN
     FITQKYKEGK FRKTLLASLT KEELNKALCA AVVKPDVLET MAILFSGADV MCATGDPVHS
     TPYLLAKKAG QSLQMEFLYH NKFSDFPQHD IHSEDGLNQD ATQSVFLCDF LYQAPAAASK
     VSSEKKLLEE TNKKWCVLEG GFLSYYENDK STTPNGTINI NEVICLAVHK EDFYLNTGPI
     FIFEIYLPSE RVFLFGAETS QAQRKWTETI AKHFVPFVAE NLTEADYDLI GQLFYKDCHA
     LDQWRKGWFA MDKSSLRFCL QMQEAQEDRM HLRRLQELTI STMVQNGEKL DVLLLVEKGR
     TLYIHGHTKL DFTVWHTAIE KAAGTDGNAL QDQQLSKNDV PIIVNSCIAF VTQYGLGCKY
     IYQKNGDPLR ISELLESFKK DARSFKLRAG KHQLEDVTGV LKSFLSDIDD ALLTKELYPY
     WISALDTQDD KERTKKYGAF IRTLPGVNRA TLAAIIEHLY RVQKCSEINH MNAHNLALVF
     SSCLFQTKGQ TSEEVNVIED LINNYVEIFE VKEDQVKQMD IENSFITKWK DTQVSQAGDL
     LIEVYVERKE PDCSIIIRIS PVMEAEELTN DILAIKNIIP TKGDIWATFE VIENEELERP
     LHYTENVLEQ VLRWSSLAEP GSAYLVVKKF LTMDVIKHHR EKSIKEGVLK IKEEPSKILS
     GNKFQDRYFV LRDGYLFLYK DPKSSKYDKM FPLSAMKFYL GVKKKMKPPT SWGLTAFSEK
     HHWHLCCESS HTQMEWMASI FIAQHEDDIW PPAGKERKRS ITKNPKIGGL PLIPIQQEAN
     ATQAQRSFES AKAELERLRL SEKRDREFMD PSLKDRASIV AQCLEHKEDK LRNRTRKHRS
     FNCLEDTESE VPRGHQKGHK GLKTLGKADD RNSKAALDTD HKLPSQVIEE LSVVLQRSRT
     LPKELQGEQI LQKEIK
//
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