ID I3MU09_ICTTR Unreviewed; 1004 AA.
AC I3MU09;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|Ensembl:ENSSTOP00000015604.2};
GN Name=SLC12A3 {ECO:0000313|Ensembl:ENSSTOP00000015604.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015604.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000015604.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR EMBL; AGTP01009397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01009398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01009399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005318265.1; XM_005318208.2.
DR AlphaFoldDB; I3MU09; -.
DR STRING; 43179.ENSSTOP00000015604; -.
DR Ensembl; ENSSTOT00000026383.2; ENSSTOP00000015604.2; ENSSTOG00000024370.2.
DR eggNOG; KOG2083; Eukaryota.
DR GeneTree; ENSGT00940000155044; -.
DR HOGENOM; CLU_001883_0_0_1; -.
DR InParanoid; I3MU09; -.
DR OrthoDB; 5490251at2759; -.
DR TreeFam; TF313191; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0015378; F:sodium:chloride symporter activity; IEA:Ensembl.
DR GO; GO:0071241; P:cellular response to inorganic substance; IEA:Ensembl.
DR GO; GO:0070294; P:renal sodium ion absorption; IEA:Ensembl.
DR GO; GO:1904044; P:response to aldosterone; IEA:Ensembl.
DR GO; GO:0002021; P:response to dietary excess; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..116
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 141..646
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 655..794
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 800..1003
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
SQ SEQUENCE 1004 AA; 111131 MW; 5DC7175834D5A6A4 CRC64;
MAQLPTMETP GDPALCRGRF TISTLLGGDE PLPPAAYDSS HPSHLTHGST FHMRTFGYNT
MDAVPAYEHY ADSALPGEPR KVRPTLADLH SFLKQEGSHL HALALDSRPS HEMTDGLVED
EARTNSDKSP GEPVRFGWVK GVMIRCMLNI WGVILYLRLP WITAQAGIVL TWVIILLSVM
VTSITGLSIS AISTNGKVKS GGTYFLISRS LGPELGGSIG LIFAFANAVG VAMHTVGFAE
TVRDLLQEYG TPIVDPINDI RIIGVATVTV LLAISLAGME WESKAQVLFF LVIMVSFANY
LVGTLIPPSE DKASKGFFSY RGDIFVQNLV PDWRGIDGSF FGMFSIFFPS ATGILAGANI
SGDLKDPAVA IPKGTLMAIF WTTVSYLAIS ATIGSCVVRD ASGDLNDTVT PGSGACEGLA
CGYGWNFTQC AQQHSCHYGL INYYQTMSMV SGFAPLITAG IFGATLSSAL ACLVSAAKVF
QCLCEDQLYP LIGFFGKGYG KNKEPVRGYL LAYAIAVAFI IIAELNTIAP IISNFFLCSY
ALINFSCFHA SITNSPGWRP SFQYYSKWTA LFGAVVSVVI MFLLTWWAAL IAIGVVLFLL
LYVIYKKPEV NWGSSVQAGS YNLALSYSVG LNEVEDHIKN YRPQCLVLTG PPNFRPALVD
FVGTFTQNLS LMICGHVLIG PRKQRMPELR LIAQGHTKWL NKRKIKAFYS DVIAEDLRSG
VQILMQAAGL GRMKPNILVV GYKKNWQSAH PATVEDYIDI LHDAFDFNYG VCVLRMREGL
NISETMQAHV DPEALVREEQ ASTIFQSEQG KKTVDIYWLF DDGGLTLLIP YLLRRKKRWS
KCKIRVFVGG QVNRMDQERK AIISLLSKFR LGFHEVHVLP DINQKPRAEH TKRFEDMIAP
FRLNDGFKDE ATVAEMRRDC PWKISDEEVN KNRIKSLRQV RLNEILLDYS REAALVVITL
PIGRKGKCPS SLYMAWLETL SQDLRPPVVL IRGNQENVLT FYCQ
//
