ID I3MUA0_ICTTR Unreviewed; 313 AA.
AC I3MUA0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Guanine nucleotide-binding protein G(q) subunit alpha {ECO:0000256|ARBA:ARBA00040847};
DE AltName: Full=Guanine nucleotide-binding protein alpha-q {ECO:0000256|ARBA:ARBA00042116};
GN Name=GNAQ {ECO:0000313|Ensembl:ENSSTOP00000015695.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000015695.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000015695.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004193};
CC Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004126}.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR EMBL; AGTP01032523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01032524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01032525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01032526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01032527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01032528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MUA0; -.
DR STRING; 43179.ENSSTOP00000015695; -.
DR Ensembl; ENSSTOT00000027748.2; ENSSTOP00000015695.2; ENSSTOG00000024755.2.
DR GeneTree; ENSGT00940000161347; -.
DR HOGENOM; CLU_014184_7_0_1; -.
DR InParanoid; I3MUA0; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000654; Gprotein_alpha_Q.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF316; GUANINE NUCLEOTIDE-BINDING PROTEIN G(Q) SUBUNIT ALPHA; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00442; GPROTEINAQ.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 313 AA; 36703 MW; EA0E00FA4A3795A4 CRC64;
TGESGKSTFI KQMRIIHGSG YSDEDKRGFT KLVYQNIFTA MQAMIRAMDT LKIPYKYEHN
KAHAQLVREV DVEKVSAFEN PYVDAIKSLW NDPGIQECYD RRREYQLSDS TKYYLNDLDR
VADPSYLPTQ QDVLRVRVPT TGIIEYPFDL QSVIFRMVDV GGQRSERRKW IHCFENVTSI
MFLVALSEYD QVLVESDNEN RMEESKALFR TIITYPWFQN SSVILFLNKK DLLEEKIMYS
HLVDYFPEYD GPQRDAQAAR EFILKMFVDL NPDSDKIIYS HFTCATDTEN IRFVFAAVKD
TILQLNLKEY NLV
//
