ID   I3MW34_ICTTR            Unreviewed;       168 AA.
AC   I3MW34;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Translin-associated protein X {ECO:0000256|ARBA:ARBA00041076};
DE   AltName: Full=Translin-associated factor X {ECO:0000256|ARBA:ARBA00042076};
GN   Name=TSNAX {ECO:0000313|Ensembl:ENSSTOP00000016329.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016329.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000016329.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Acts in combination with TSN as an endonuclease involved in
CC       the activation of the RNA-induced silencing complex (RISC). Possible
CC       role in spermatogenesis. {ECO:0000256|ARBA:ARBA00037653}.
CC   -!- SUBUNIT: Ring-shaped heterooctamer of six TSN and two TSNAX subunits.
CC       Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the
CC       homodimeric form of C1D following gamma-radiation. Interacts with TSN
CC       and C1D in a mutually exclusive manner.
CC       {ECO:0000256|ARBA:ARBA00038594}.
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DR   EMBL; AGTP01017323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01017324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01017325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005320428.1; XM_005320371.2.
DR   AlphaFoldDB; I3MW34; -.
DR   STRING; 43179.ENSSTOP00000016329; -.
DR   Ensembl; ENSSTOT00000019756.2; ENSSTOP00000016329.2; ENSSTOG00000024989.2.
DR   GeneID; 101967727; -.
DR   CTD; 7257; -.
DR   eggNOG; KOG3066; Eukaryota.
DR   GeneTree; ENSGT00940000153568; -.
DR   HOGENOM; CLU_125030_0_0_1; -.
DR   InParanoid; I3MW34; -.
DR   OrthoDB; 10121at2759; -.
DR   TreeFam; TF323633; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:1902555; C:endoribonuclease complex; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030422; P:siRNA processing; IEA:Ensembl.
DR   InterPro; IPR002848; Translin_fam.
DR   InterPro; IPR016068; Translin_N.
DR   InterPro; IPR036081; Translin_sf.
DR   PANTHER; PTHR10741; TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X; 1.
DR   PANTHER; PTHR10741:SF5; TRANSLIN-ASSOCIATED PROTEIN X; 1.
DR   Pfam; PF01997; Translin; 1.
DR   SUPFAM; SSF74784; Translin; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR602848-1};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR602848-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         129
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602848-1"
SQ   SEQUENCE   168 AA;  19319 MW;  20C7C98BBD5BCED2 CRC64;
     MSGKEGPGGF RKRKHDNFPH GQRREGKDVS ASSPVMLAFK SFQQELDARH DKYERLVKLS
     RDITVESKRT IFLLHRITSA PDMEEILTES EVKLDGVRQK ILQVAQELSG EDMHQFHRAI
     TTGLQEYVEA VSFQHFIKTR SLISMDEINK ELVFTTEDSG KENKTVRT
//