ID I3MWN9_ICTTR Unreviewed; 979 AA.
AC I3MWN9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Zinc finger BED-type containing 6 {ECO:0000313|Ensembl:ENSSTOP00000016534.1};
GN Name=ZBED6 {ECO:0000313|Ensembl:ENSSTOP00000016534.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016534.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01062179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005330372.1; XM_005330315.2.
DR AlphaFoldDB; I3MWN9; -.
DR STRING; 43179.ENSSTOP00000016534; -.
DR Ensembl; ENSSTOT00000026943.1; ENSSTOP00000016534.1; ENSSTOG00000022677.1.
DR eggNOG; KOG1121; Eukaryota.
DR GeneTree; ENSGT00940000163411; -.
DR HOGENOM; CLU_303823_0_0_1; -.
DR InParanoid; I3MWN9; -.
DR OMA; YTWRAIC; -.
DR OrthoDB; 3084694at2759; -.
DR TreeFam; TF322818; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR GO; GO:0051148; P:negative regulation of muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR003656; Znf_BED.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR47241; FINGER PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR47241:SF2; ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF02892; zf-BED; 2.
DR SMART; SM00614; ZnF_BED; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF140996; Hermes dimerisation domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50808; ZF_BED; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00027}.
FT DOMAIN 130..187
FT /note="BED-type"
FT /evidence="ECO:0000259|PROSITE:PS50808"
FT DOMAIN 265..322
FT /note="BED-type"
FT /evidence="ECO:0000259|PROSITE:PS50808"
FT REGION 201..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 109724 MW; 38740A46E779F09C CRC64;
MSVCTLSAPV SSLSPRRRCR TFNGAGILGC VSINSNAAEE DVVEGKMVAE GVDKEAKLPA
KKKRKKGLRI KGKRRRKKLI LAKKFTKDLG SGRPVADAPA LLAPTASEQD EESLFESNIE
KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI CNLCEKSVSR GKPGSHLGTS TLQRHLQARH
SPHWTRANKF GVTSGEEDFS LDVSLSPSSP GSNGSFDYIP ADSLDDNRMG KKRDKSASDA
LRAERGRFLI KSNIVKHALI PGTRAKTSAV WNFFYTDPQH ISRAVCNICK RSVSRGRPGS
HLGTSTLQRH LQATHPIHWA VANKDSGALG NGLDETETES SDLLNDTHGE KSTGSQDLTA
EDLSDSDSDE PPVLEVENRS DSPIPVVEQD SLMHEQERET TYCENPASSQ ISQAIIQMIV
EDMHPYNYFS TPAFQRFLQI VAPDYRLPSE TYFFTKVVPQ LYDCVREKIF LTLENVQSQK
IHLTVDIWTH DPSTDYFIVT VHWVSLETDS SPNNGRIPSF RKWAVLCVTG LAKDCLITNI
LQELNDQIGL WLSPNFLIPS FIVSDNSSNV VHAIKDGGFT HVPCFLHCLN IVIQDFFCEH
KSIENMLVAA RKTCHHFSHS VKARQILQEF QNDHQLPWKN LKQDETGHWI STFYMLKWLL
EHCYSVHHSL GRASGVVLTS LQWTLMTYVC DILKPFEEAT QKVSVKTTGL NQVLPLIHHL
LLSLQKLRED FQVRGITQAL NLVDSLSLKL ETDTLLSAML KSKPCILATL LDPCFKNSLE
DFFPQGADLE IYKQILAEEV CNYMESSPET CQIAASEASG PLVTVGVDSY TSSIKEGTSN
SGSMDIPATD TVAIGSKGFM FPSAIAVVDE YFKEKYSELS GGDDPLIYWQ RKLSIWPALT
QVAIQYLSCP MCSWQSECIF TSNSHFHPKQ IMSLDFDNIE QLMFLKMNLK NVNYDYSALV
LSQDPQNKVV QSNEKEILS
//
