ID I3MWV7_ICTTR Unreviewed; 395 AA.
AC I3MWV7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=COBW domain containing 1 {ECO:0000313|Ensembl:ENSSTOP00000016602.2};
GN Name=Cbwd1 {ECO:0000313|Ensembl:ENSSTOP00000016602.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016602.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016602.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01031961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005324144.1; XM_005324087.1.
DR AlphaFoldDB; I3MWV7; -.
DR STRING; 43179.ENSSTOP00000016602; -.
DR Ensembl; ENSSTOT00000024945.2; ENSSTOP00000016602.2; ENSSTOG00000028764.2.
DR GeneID; 101961141; -.
DR CTD; 55871; -.
DR eggNOG; KOG2743; Eukaryota.
DR GeneTree; ENSGT00640000091523; -.
DR HOGENOM; CLU_017452_0_1_1; -.
DR InParanoid; I3MWV7; -.
DR OrthoDB; 1010489at2759; -.
DR TreeFam; TF332679; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0140827; F:zinc chaperone activity; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051604; P:protein maturation; IEA:Ensembl.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF31; COBW DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 274..377
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 44031 MW; DBECCB1323ADFD66 CRC64;
MLQTAGAQDE EEEHAEEDCP ELVPIETKQG EEEEKPGPGA KIPVTIITGY LGAGKTTLLN
YILTEQHSKK IAVILNEFGE GSAVEKSLAI SQGGELYEEW LELGNGCLCC SVKDNGLRAI
ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITVVD SKYGLKHLTE
EKPDGLISEA TRQVALADII LINKTDLISE EELNKLRAII RSINGLGKIL ETQRSRVDLS
NVLDLHAFDS LSGISLQKKL QHVSATQSHL DQSIVTITFE VPGNSKEDSL NIFIQNLLWE
KNVRNKDNRC MEVIRLKGLV SIKDKPQQVI VQGVHELYDL EETPVSWEDD AERTNRLVFI
GRNLDKNILK QLFIATVTET EKQWTTQFKE DQVCP
//