ID I3MXJ4_ICTTR Unreviewed; 188 AA.
AC I3MXJ4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 5 {ECO:0000256|ARBA:ARBA00019580, ECO:0000256|PIRNR:PIRNR037610};
DE Short=BLOC-1 subunit 5 {ECO:0000256|PIRNR:PIRNR037610};
DE AltName: Full=Protein Muted homolog {ECO:0000256|ARBA:ARBA00031992, ECO:0000256|PIRNR:PIRNR037610};
GN Name=BLOC1S5 {ECO:0000313|Ensembl:ENSSTOP00000016839.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000016839.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000016839.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO).
CC {ECO:0000256|PIRNR:PIRNR037610}.
CC -!- SIMILARITY: Belongs to the BLOC1S5 family.
CC {ECO:0000256|ARBA:ARBA00010754, ECO:0000256|PIRNR:PIRNR037610}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01048682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01048683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01048684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01048685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005327538.1; XM_005327481.1.
DR AlphaFoldDB; I3MXJ4; -.
DR STRING; 43179.ENSSTOP00000016839; -.
DR Ensembl; ENSSTOT00000023597.2; ENSSTOP00000016839.2; ENSSTOG00000027342.2.
DR GeneID; 101955494; -.
DR CTD; 63915; -.
DR eggNOG; ENOG502S2QH; Eukaryota.
DR GeneTree; ENSGT00390000016974; -.
DR HOGENOM; CLU_110751_1_0_1; -.
DR InParanoid; I3MXJ4; -.
DR OrthoDB; 5232538at2759; -.
DR TreeFam; TF332943; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; IEA:Ensembl.
DR GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; IEA:Ensembl.
DR GO; GO:0035646; P:endosome to melanosome transport; IEA:Ensembl.
DR GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
DR GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl.
DR GO; GO:0050942; P:positive regulation of pigment cell differentiation; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:Ensembl.
DR InterPro; IPR017243; Bloc1s5.
DR PANTHER; PTHR31784; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5; 1.
DR PANTHER; PTHR31784:SF2; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5; 1.
DR Pfam; PF14942; Muted; 1.
DR PIRSF; PIRSF037610; BLOC-1_complex_muted_subunit; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 21910 MW; 65FC5002146CFF34 CRC64;
MSGGGTETLV GCEVAPGGGG GKKRDSLGTA GSAHLIIKDL GEIHSRLLDH RPVIQGETRY
FVKEFEEKRG LREMRVLENL KNMIHETNEH TLPKCRETMQ DNLKEVLQRL QAANDSVCRL
QQREQERRKM YHDHLIATEK QHQLQWEDFM KEQPRRQAEV DEEHRRAMER LKEQYAEMEK
GLAKFSTF
//
