ID I3MYC3_ICTTR Unreviewed; 557 AA.
AC I3MYC3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Potassium voltage-gated channel modifier subfamily V member 2 {ECO:0000313|Ensembl:ENSSTOP00000017119.1};
GN Name=KCNV2 {ECO:0000313|Ensembl:ENSSTOP00000017119.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017119.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017119.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGTP01031839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005324131.1; XM_005324074.1.
DR AlphaFoldDB; I3MYC3; -.
DR STRING; 43179.ENSSTOP00000017119; -.
DR Ensembl; ENSSTOT00000021600.2; ENSSTOP00000017119.1; ENSSTOG00000020003.2.
DR GeneID; 101957999; -.
DR CTD; 169522; -.
DR eggNOG; KOG3713; Eukaryota.
DR GeneTree; ENSGT00940000157438; -.
DR HOGENOM; CLU_011722_4_1_1; -.
DR InParanoid; I3MYC3; -.
DR OMA; YQAVAIY; -.
DR OrthoDB; 1478695at2759; -.
DR TreeFam; TF313103; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF40; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY V MEMBER 2; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 263..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..199
FT /note="Potassium channel tetramerisation-type BTB"
FT /evidence="ECO:0000259|Pfam:PF02214"
FT DOMAIN 271..516
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 63837 MW; BC3DC517F32C1879 CRC64;
MLKQTNKRRG SWSYKPWSAL ESEDPPSTGT NQHRRSSTGT RSGSHGSITP WTEVRYNYYI
EEDDSGGEEE EEWKDNLAKE DQQPGEITTA QLDGHTDTPA HLSMLNVNVG GHSYQLDYCE
LASYPKTRLG RLVTSMTRSR QLGLCDDYEA KTDEYFFDRD PDVFQLVYNF YTSGVLLVRD
ELCPQNFLEE LGYWGVRLKY TPRCCRICFE ERREELSEQL KIQRELRAQA QAEEAEELFR
DMRFCGAQRR RLWNFMEKPF SSVAAKVMGV ASNLFVLISV VTLTLNTVEE MQHQAEEGTG
GDPGSILEHL EVLCVAFFTL EYLLRLISTP DLRRFARSAL NLVDLVAILP LYLQLLLEGF
TEEVQGYSRG STHDQDLETV GRVGKVGQVL RIMRLMRIFR ILKLARHSTG LRAFGFTLLQ
CYQQVGCLLL FITLGIFTFS AAVYSVEHDV PGTNFTSILQ AWWWAAVSLS TVGYGDMYPE
TLLGRLFAFL CIAFGIILNG MPISILYNKF SDYYSKLKAY EYTAIRRERG NVDFMQRARK
KMAECLARSN TQPTPRQ
//
