ID I3MYL9_ICTTR Unreviewed; 839 AA.
AC I3MYL9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Patched domain containing 3 {ECO:0000313|Ensembl:ENSSTOP00000017215.2};
GN Name=PTCHD3 {ECO:0000313|Ensembl:ENSSTOP00000017215.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017215.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017215.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; AGTP01076469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MYL9; -.
DR STRING; 43179.ENSSTOP00000017215; -.
DR Ensembl; ENSSTOT00000025679.2; ENSSTOP00000017215.2; ENSSTOG00000022182.2.
DR eggNOG; KOG1933; Eukaryota.
DR GeneTree; ENSGT00940000158727; -.
DR HOGENOM; CLU_002359_2_1_1; -.
DR InParanoid; I3MYL9; -.
DR TreeFam; TF331806; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF60; PATCHED DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..430
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 839 AA; 96169 MW; 99782B335C75844A CRC64;
RCYTNCLEKP LSRAFERLGR CVGSHPWIFL LVPILLTAAL GIGFIYLPKE EEENLEEQYT
PIGSPAKAER RFVQAHFTTN DSYRFSSTRS SSENNFASIL VVSNSETLLE SEIFEEVSQL
DQAVQTLSVR KENGAPIHYK EVCAKYRTFC VPSNPLLYVW QRNKTLDLKT FTFPMHNYKN
HFIYLAGFFG GNTLGDSVGQ NHLLLETKAM RLLYYLKTEV KEDSEQSKEW LVHFLDEFYS
LKEKLAFKNI QVQVVHFTSL SRQLEFEATS MTVVPLFHLA YLLIIIFAII SCYRFDCVRN
KMWVAVFGVV SAAFAVVSGF GLMLYIGVPF VIIVANSPFL ILGVGVDDMF IMISAWQKTS
LMDSIKERMA TVYSKVAVSI TITTITNVLA FYTGIMSSFR SVQYFCIYTG TTLLFCYFYN
ITCFGAFMAL DGKREILCLR WLKKPDQKYS SLKKACCLPF SSVPDEQGTD IHPMNLFFRD
YFGPVLTRTM SKFFVVVIYI LYIISSIYGC FQVQEGLDLR NLASDDSYIT PYFNVEEDYF
SEYGPRVMII ITESINYWDE DVREKLEKCI ENFKENDYVE RNLTEFWLHT YMDYMKRNGQ
DPNDKNTFMN GMSHFLRKFP VFTYDINITS NEIISSRGFI QTMGVSSSTN KKIMLLQLRE
TAEKCEIPLM VYNQAFIYFD QYAAIIENTV RNIMVASTAM FIVSLLLIPH PMCSLWVTFA
IASVIVGVTG FMAFWNVNLD SISMINLVIC IGFSFDFSAH ISYAFVSSTK TSVNQKSIEA
LYLLGYPVLQ SAISTIIGVC VLATAKAYIF RTFFKIMFLV MVFGAAHGLI FIPVFLTFF
//
