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Database: UniProt
Entry: I3MZ17_ICTTR
LinkDB: I3MZ17_ICTTR
Original site: I3MZ17_ICTTR 
ID   I3MZ17_ICTTR            Unreviewed;       395 AA.
AC   I3MZ17;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   11-DEC-2019, entry version 40.
DE   SubName: Full=NHL repeat containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSSTOP00000017363};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSSTOP00000017363};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017363, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000017363}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000017363}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
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DR   EMBL; AGTP01056465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005329201.1; XM_005329144.1.
DR   STRING; 43179.ENSSTOP00000017363; -.
DR   Ensembl; ENSSTOT00000020126; ENSSTOP00000017363; ENSSTOG00000028904.
DR   GeneID; 101973355; -.
DR   CTD; 378884; -.
DR   eggNOG; ENOG410ITF2; Eukaryota.
DR   eggNOG; ENOG410ZMHC; LUCA.
DR   GeneTree; ENSGT00730000111361; -.
DR   InParanoid; I3MZ17; -.
DR   OrthoDB; 711255at2759; -.
DR   TreeFam; TF331018; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 2.120.10.30; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN          26..72
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REPEAT          113..157
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          161..204
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          212..245
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          251..300
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          325..349
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          350..393
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ   SEQUENCE   395 AA;  41967 MW;  D7F1F5F26F77160B CRC64;
     MGEEASGGGG TPRELVREAE IGLLECKVCF ERFGHSQQRR PRNLACGHVV CLACVAALAH
     PRTLALECPF CRRACRACDT SDCLPVLHLL ELLGSTLHRS PAAPCAAPCI PGALSCHHAF
     GGWGTLVNPT GLALCPKTGR VVVVHDGKRR VKIFDSGGGC VHQFGEKGDA AQDIRYPLDV
     TVTSDCHVVV TDAGDRSVKV FDFFGQIKLV MGGQFSLPWG VETTPQNGVL VTDAEGGSLH
     LLEVDFLEGA LQRTERLQAH LSSPRGVAVS WLTGAVAVLE HPWALGPGAC SSRVKVFSSS
     MQLIGQVDTF GLSLFFPSRV TASAVTFDHQ GNVVVTDTSG PAILCLGKPE EFPGLKPMVT
     EGLSHPVALT FTKENSLLVL DTASHSVKVY KADWG
//
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