ID I3MZ98_ICTTR Unreviewed; 302 AA.
AC I3MZ98;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Histone-lysine N-methyltransferase SETMAR {ECO:0000313|Ensembl:ENSSTOP00000017444.1};
GN Name=LOC101962206 {ECO:0000313|Ensembl:ENSSTOP00000017444.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017444.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017444.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
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DR EMBL; AGTP01065384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005331018.1; XM_005330961.2.
DR AlphaFoldDB; I3MZ98; -.
DR STRING; 43179.ENSSTOP00000017444; -.
DR Ensembl; ENSSTOT00000027309.2; ENSSTOP00000017444.1; ENSSTOG00000025520.2.
DR GeneID; 101962206; -.
DR eggNOG; KOG1082; Eukaryota.
DR GeneTree; ENSGT00940000162663; -.
DR HOGENOM; CLU_020840_3_3_1; -.
DR InParanoid; I3MZ98; -.
DR OMA; VDSMVPK; -.
DR OrthoDB; 5481936at2759; -.
DR TreeFam; TF316038; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProt.
DR CDD; cd10544; SET_SETMAR; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46223:SF3; HISTONE H3 (LYS9) METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR46223; HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 60..124
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 127..251
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 271..287
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
SQ SEQUENCE 302 AA; 33779 MW; 9BA422C3B6AA04E5 CRC64;
MAASEEETEA LTGLLDVARG LENLPVSAWP PGARLAPFQY TPDHVVGPGA DIDPTEITFP
GCTCVTTPCI PGTCSCLRHE ENYDGSQCLR DMGSSEATYA RPVFECNVLC QCGEHCRNRV
VQRGLQFHLQ VFKTEKKGWG LRTLEFIPKG RFVCEYAGEV LGSSEVQRRV RLQTAQDSNY
IIAIREHVCD GQVMETFVDP TYVGNAGRFL NHSCEPNLLM IPVRIDSMVP KLALFAAKDI
WPGEELSYDY SGRFLNLMDR EAKERLHDEK LRKLCHCGAK SCLAFLPYDS SLYCPLEKLD
SN
//
