ID I3MZS2_ICTTR Unreviewed; 222 AA.
AC I3MZS2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=MIF4G domain containing {ECO:0000313|Ensembl:ENSSTOP00000017618.1};
GN Name=MIF4GD {ECO:0000313|Ensembl:ENSSTOP00000017618.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017618.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017618.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions in replication-dependent translation of histone
CC mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC with a poly-A tail but a stem-loop. May participate in circularizing
CC those mRNAs specifically enhancing their translation.
CC {ECO:0000256|ARBA:ARBA00037643}.
CC -!- SUBUNIT: Interacts with eif4g1, eif4g2 and slbp; probably tethered by
CC SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC interacts with eif4g1 which is bound to their 5'-end.
CC {ECO:0000256|ARBA:ARBA00038641}.
CC -!- SIMILARITY: Belongs to the MIF4GD family.
CC {ECO:0000256|ARBA:ARBA00038204}.
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DR EMBL; AGTP01070498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MZS2; -.
DR STRING; 43179.ENSSTOP00000017618; -.
DR Ensembl; ENSSTOT00000026075.2; ENSSTOP00000017618.1; ENSSTOG00000022390.2.
DR eggNOG; KOG3942; Eukaryota.
DR GeneTree; ENSGT00940000153432; -.
DR HOGENOM; CLU_081010_1_0_1; -.
DR InParanoid; I3MZS2; -.
DR OMA; QQEFKGR; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0062073; C:histone mRNA stem-loop binding complex; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0002191; P:cap-dependent translational initiation; IEA:Ensembl.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR23254; EIF4G DOMAIN PROTEIN; 1.
DR PANTHER; PTHR23254:SF17; MIF4G DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 3..205
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
SQ SEQUENCE 222 AA; 25397 MW; 1DBA17FBCC990D87 CRC64;
MGEASREEYK IQSFDAETQQ LLKTALKDPG AVDLEKVANV IVDHSLQDCV FSKEAGRMCY
AIIQAESKQA GQSVFRRGLL NRLQQEYQAR EQLRARSLQG WVCYVTFICN IFDYLRVNNM
PMMALVNPVY DCLFRLAQPD SLSKEEEVDC LVLQLHRVGE QLEKMNGQRM DELFVLIRDG
FLLPTGLSSL AQLLLLEIIE FRAAGWKTTP AAHKYYYSEV SD
//
