ID I3N052_ICTTR Unreviewed; 423 AA.
AC I3N052;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Cytokine dependent hematopoietic cell linker {ECO:0000313|Ensembl:ENSSTOP00000017748.2};
GN Name=CLNK {ECO:0000313|Ensembl:ENSSTOP00000017748.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000017748.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000017748.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01011547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01011548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01011549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01011550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01011551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01011552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N052; -.
DR STRING; 43179.ENSSTOP00000017748; -.
DR Ensembl; ENSSTOT00000024953.2; ENSSTOP00000017748.2; ENSSTOG00000014009.3.
DR eggNOG; ENOG502S0EU; Eukaryota.
DR GeneTree; ENSGT00940000161846; -.
DR HOGENOM; CLU_052668_0_0_1; -.
DR InParanoid; I3N052; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0042629; C:mast cell granule; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0043303; P:mast cell degranulation; IEA:Ensembl.
DR GO; GO:0032815; P:negative regulation of natural killer cell activation; IEA:Ensembl.
DR GO; GO:0002729; P:positive regulation of natural killer cell cytokine production; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR14098:SF2; CYTOKINE-DEPENDENT HEMATOPOIETIC CELL LINKER; 1.
DR PANTHER; PTHR14098; SH2 DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 308..418
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..184
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 48265 MW; BA04C1D3EE28369C CRC64;
MNSLGNKRTT KEKSSDLKFQ NSTLLKNRSW PHLHRTTAQD QAIRQPLPRR ERKLAAAPDV
TEYHSEDEYE DPELQMVDVW PSLKILPARP IKESEYADKR CFKRVMDTSP PLHSKASLPS
LGPSWNMWTR LEEVDRAVSK DMRRLHTREN RSIKGNMTPL PPPRPPTTLP KQHQPLPPAP
ESSAPLPQRH TSPEAQGGPR QISLKDLRGV LEAEEVSHDK MRPASSQPSQ SRITRKIPLA
LTSSSFVRSH DNLQDRDGEG SMQACSAQRC QSPASHGPPG NTLPHPDTSW REPFPAPSDE
KEVRHYEWYV GRYSRQAVEE ALMKENKDGT FLVRDHSTKS KAEPYVLVVF YGNKVYNVKI
RFLEKSQQFA LGTGLRGDEK FDSVEDIIEY YQYFPITLID GKDKTGVHRE QCYLTQPLTL
PGH
//
