ID I3N1J6_ICTTR Unreviewed; 884 AA.
AC I3N1J6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO6 {ECO:0000313|Ensembl:ENSSTOP00000018242.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018242.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000018242.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01037109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01037118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N1J6; -.
DR STRING; 43179.ENSSTOP00000018242; -.
DR Ensembl; ENSSTOT00000026785.2; ENSSTOP00000018242.2; ENSSTOG00000024923.2.
DR eggNOG; KOG2514; Eukaryota.
DR GeneTree; ENSGT00940000158969; -.
DR HOGENOM; CLU_006685_1_4_1; -.
DR InParanoid; I3N1J6; -.
DR TreeFam; TF314265; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:Ensembl.
DR GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR GO; GO:0017128; F:phospholipid scramblase activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:Ensembl.
DR GO; GO:0002543; P:activation of blood coagulation via clotting cascade; IEA:Ensembl.
DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0045794; P:negative regulation of cell volume; IEA:Ensembl.
DR GO; GO:0097045; P:phosphatidylserine exposure on blood platelet; IEA:Ensembl.
DR GO; GO:0046931; P:pore complex assembly; IEA:Ensembl.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0034767; P:positive regulation of monoatomic ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0035590; P:purinergic nucleotide receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IEA:Ensembl.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF21; ANOCTAMIN-6; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 272..299
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 433..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 480..501
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 528..546
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 695..719
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 799..820
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 35..258
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 261..844
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
SQ SEQUENCE 884 AA; 102926 MW; 30F0D2AE26DE1663 CRC64;
MQMMTRNVLL DMELEEDDDE DGDIEEFNGK PDSLFFNDGQ RRIDFVLVYE DESRKETNKK
GTNEKQRRKR QAYESNLICQ GLQLEATRSV LDDKIVFVKV HAPWDVLCTY AEIMHIKLPL
KPNDLKTRSS AFDSFNWFTK VLRVDERLIK PEQEFFTAPF EKNRMNDFYI VDKDSFFNPA
TRSRIVYFIL SRVKYQVVNN VSKFGINRLV SSGIYKAAFP LHDCQFGSRS EDPSCPNERY
LLYREWAHPR SIYKKQPLDL IRKYYGEKIG IYFAWLGYYT QMLLLAAVVG VACFLYGYLN
QDNCTWSKEV CDPDIGGKIV MCPQCDKICP FWKLNITCES SKKLCIFDSF GTLVFAVFMG
VWVTLFLEFW KRRQAELEYE WDTVELQQEE QPRPEYEAQC THVVINEITQ EEERIPFTAW
GKCIRVTLCA SAVLFWILLI IASVIGIIVY RLSVFIVFSA KLPSTVNGTD PIQKYLTPQT
ATSITASIIS FIIIMILNTI YEKVAIMITN FELPRTQTDY ENSLTMKMFL FQFVNYYSSC
FYIAFFKGKF VGYPGDPVYW LGKYRNEECD PGGCLLELTT QLIIIMGGKA IWNNIQEVLL
PWIMNLIGRY HSVSGSEKKT PRWEQDYHLQ PMGKLGLFYE YLEMIIQFGF VTLFVASFPL
APLLALVNNI LEIRVDAWKL TTQFRRMVPE KAQDIGAWQP IMQGIAILAV VTNAMIIAFT
SDMIPRLVYY WSFSIPPYGD HTHYTMEGYI SNTLSIFNIA DFKNKSKGDS FSGLGDHTTC
RYRDFRNPPG HPQEYKHNIY YWHVIAAKLA FIIVMEHIIY SVKFLISYII PDVSKSTRSK
IKREKYLTQK LLHESHLKDM TKNMGAIAER MVEVVDNNLR PKLE
//
