ID I3N1K7_ICTTR Unreviewed; 918 AA.
AC I3N1K7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tight junction protein 3 {ECO:0000313|Ensembl:ENSSTOP00000018253.2};
GN Name=TJP3 {ECO:0000313|Ensembl:ENSSTOP00000018253.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018253.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000018253.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AGTP01068834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01068835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N1K7; -.
DR STRING; 43179.ENSSTOP00000018253; -.
DR Ensembl; ENSSTOT00000024832.2; ENSSTOP00000018253.2; ENSSTOG00000024962.2.
DR eggNOG; KOG3580; Eukaryota.
DR GeneTree; ENSGT00940000160036; -.
DR HOGENOM; CLU_006234_0_0_1; -.
DR InParanoid; I3N1K7; -.
DR TreeFam; TF315606; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005420; ZO-3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF11; TIGHT JUNCTION PROTEIN ZO-3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01600; ZONOCCLUDNS3.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 19..104
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 206..283
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 388..454
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 483..556
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 561..768
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 106..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..330
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 100269 MW; E3B4BDEDF3B0B836 CRC64;
MTSAQVASME ALTIWEQHTA TLCKDPRRGF GIAISGGRDR PSAPGGSVVV SDVVPGGPAE
GRLLTGDHIV MVNGVSVESV SSAFVIQILR TCAKVANVTV KRPRRVQLPA TKASPSSPGH
PDSDEEDGPR RLEEPDHGQG YEGDSSSGSG HSRGERSRRA RAGRRSRASS RGRRSPGGGS
EAPGLALVSG FKRLPRQDVL MKPLKSVLVK RKDSEEFGVK LGSQIFIKHI TESGLAARHR
GLQEGDLILQ INGVSSENLS LSDTRRLIEK SEGQLTLLVL RDRGQFLVNI PPAVSDSDSS
VLEDISDLTS ELSQAPPSHV PPPPRQAHRP QSPEGSPAES PVEHPRPRQE GPVDPRTFLD
RDSPSGSSYD LYRVPSHQGL EDRGYSPDTR VVRFPKGASI GLRLAGGNDV GIFVSGVQAG
SPADGQDIQA GDQILQVNET SFRNLTREEA VQFLLGLPPG EEVALLMQRK QDIFQKMVQS
RVGDSFYVRT HFELEPSPPS GLGFTRGDVF HVVDTLYPGP GPGHRGGHWL AARMGRDLRE
QERGLIPNQS RAEQLASLEA AQRAVGLGPG PSGASNARAE FWRLRGLRRG AKKTTQRSRE
DLSALTRQGR YPPYERVVLR EASFKRPVVI LGPVADIAMH KLTADLPAQF EIAESISRTD
SPSKIIKLDT VRVIAEKDKH ALLDVTPSAI ERLNYVQYYP IVIFCAPESR AALKALREWL
APASRRSSRR LYTQAQKLRK HSSHLFTATI ALQGTSDAWY QELKATIQEQ QTRPIWTAED
QLDGSSEDNL DLPHRGLAGS SADLSCDSRA NSDYETDGEG CTDGEGGPHT DVEEGPPAPA
LARSSEPVQL DEPQSPRHPG DIPAHREPQV NSRHPQGQWR QDSMRTYERE ALRRKFTRAR
DAESSDEEGY DWGPATDL
//
