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Database: UniProt
Entry: I3N2N1_ICTTR
LinkDB: I3N2N1_ICTTR
Original site: I3N2N1_ICTTR 
ID   I3N2N1_ICTTR            Unreviewed;       133 AA.
AC   I3N2N1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=C-C motif chemokine ligand 21 {ECO:0000313|Ensembl:ENSSTOP00000018627.2};
GN   Name=CCL21 {ECO:0000313|Ensembl:ENSSTOP00000018627.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018627.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000018627.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000256|ARBA:ARBA00010868}.
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DR   EMBL; AGTP01043530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3N2N1; -.
DR   STRING; 43179.ENSSTOP00000018627; -.
DR   Ensembl; ENSSTOT00000028015.2; ENSSTOP00000018627.2; ENSSTOG00000021913.2.
DR   eggNOG; ENOG502S8D1; Eukaryota.
DR   GeneTree; ENSGT01100000263557; -.
DR   HOGENOM; CLU_141716_3_2_1; -.
DR   InParanoid; I3N2N1; -.
DR   OMA; CKRTEQP; -.
DR   TreeFam; TF338224; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0001768; P:establishment of T cell polarity; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0035759; P:mesangial cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:2000669; P:negative regulation of dendritic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:1903237; P:negative regulation of leukocyte tethering or rolling; IEA:Ensembl.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IEA:Ensembl.
DR   GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   GO; GO:2000529; P:positive regulation of myeloid dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0031274; P:positive regulation of pseudopodium assembly; IEA:Ensembl.
DR   GO; GO:2000406; P:positive regulation of T cell migration; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR   GO; GO:0034695; P:response to prostaglandin E; IEA:Ensembl.
DR   GO; GO:0031529; P:ruffle organization; IEA:Ensembl.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF72; C-C MOTIF CHEMOKINE 21; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE   3: Inferred from homology;
KW   Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..133
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012113213"
FT   DOMAIN          28..90
FT                   /note="Chemokine interleukin-8-like"
FT                   /evidence="ECO:0000259|SMART:SM00199"
FT   REGION          88..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  14874 MW;  F11F08EF1E2F0FDA CRC64;
     MAQTLALSLL ILVLALCVPW TQGSDGGAQD CCLKYSQRKI PYKVVRGYRK QEASLGCPIP
     AILFLPQKRS QPELCGDPKE AWVQQLMKRL DKPPAPRKEG QGCRKDRETQ KPGKKRKGSK
     GCKRTEEPRT PKG
//
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