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Database: UniProt
Entry: I3N2X9_ICTTR
LinkDB: I3N2X9_ICTTR
Original site: I3N2X9_ICTTR 
ID   I3N2X9_ICTTR            Unreviewed;       740 AA.
AC   I3N2X9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 70.
DE   SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSSTOP00000018725.2};
GN   Name=SLC26A6 {ECO:0000313|Ensembl:ENSSTOP00000018725.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018725.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000018725.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; AGTP01046135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005326939.1; XM_005326882.2.
DR   RefSeq; XP_013214885.1; XM_013359431.1.
DR   RefSeq; XP_013214886.1; XM_013359432.1.
DR   STRING; 43179.ENSSTOP00000031877; -.
DR   Ensembl; ENSSTOT00000021492.2; ENSSTOP00000018725.2; ENSSTOG00000027369.2.
DR   Ensembl; ENSSTOT00000030287.1; ENSSTOP00000031877.1; ENSSTOG00000027369.2.
DR   GeneID; 101956856; -.
DR   CTD; 65010; -.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   OrthoDB; 1067648at2759; -.
DR   TreeFam; TF313784; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR   GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0019531; F:oxalate transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071332; P:cellular response to fructose stimulus; IEA:Ensembl.
DR   GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR   GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0050892; P:intestinal absorption; IEA:Ensembl.
DR   GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR   GO; GO:0015797; P:mannitol transmembrane transport; IEA:Ensembl.
DR   GO; GO:0046724; P:oxalic acid secretion; IEA:Ensembl.
DR   GO; GO:2001150; P:positive regulation of dipeptide transmembrane transport; IEA:Ensembl.
DR   GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR   GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF113; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        90..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        170..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        242..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        273..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        363..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        426..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        457..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          513..723
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          594..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  81172 MW;  533EFD87D1549C8F CRC64;
     MELQKQDYHV DRPLMNQEQL EELGRWDLTP RTYQWRTWLK CSHARARALL IQHLPVLGWL
     PRYPVRDWLL GDLLSGLSVA IMQLPQGLAY ALLAGLPPVF GLYSSFYPVF IYFLFGTSRH
     ISVGTFAVMS VMVGSVTESL APDENFLLDS NSTVNETARD VTRVQLASTL SVLVGLFQVG
     LGLVHFGFVV TYLSEPLVRS YTTAASVQVF VSQLKYVFGL QLSSHSGPLS LIYIVLEVCW
     KLPQSVIGTV ITALVAGVVL VMVKLLNDKL QRYLPLPIPG ELLTLIGATG ISYGVGLKQR
     FGVDVVGNIP AGLVSPEAPN PQLFVKLVGN AFAIAVVGFA IAISLGKIFA LRHGYRVDSN
     QELVALGLSN LIGGIFQCFP VSCSMSRSLV QESTGGNTQV AGAVSSLFIL LIILKLGELF
     QDLPRAVLAA TIIVNLKGML MQFADICSLW KKNRVDLLIW LVTFVATILL NLDLGLAVAL
     AFSLLLVVVR TQLPHYSVLG QVSDTDIYRD VAEYSDAREV PGVKIFRSSA TIYFANAELY
     SDTLKQRCGV DVDHLISRKK KLLKKQEMKL KRLQKHKSPQ EQAVSSQDNS VSINVNTNLG
     DIKSNDVESS KTKARPENEL EEIVASGQED AKAIAVPTLK ALGLPQPDFH SLILDLGALS
     FVDTVCIKNL KNIFRDFREI EVDVYIAACH SPVVTQLEAG QFFDASITKR HLFVSVHDAV
     TFALQHSKSG PISPVLATKL
//
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