ID I3N2X9_ICTTR Unreviewed; 740 AA.
AC I3N2X9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSSTOP00000018725.2};
GN Name=SLC26A6 {ECO:0000313|Ensembl:ENSSTOP00000018725.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018725.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000018725.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR EMBL; AGTP01046135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005326939.1; XM_005326882.2.
DR RefSeq; XP_013214885.1; XM_013359431.1.
DR RefSeq; XP_013214886.1; XM_013359432.1.
DR STRING; 43179.ENSSTOP00000031877; -.
DR Ensembl; ENSSTOT00000021492.2; ENSSTOP00000018725.2; ENSSTOG00000027369.2.
DR Ensembl; ENSSTOT00000030287.1; ENSSTOP00000031877.1; ENSSTOG00000027369.2.
DR GeneID; 101956856; -.
DR CTD; 65010; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01070000253775; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR OrthoDB; 1067648at2759; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0071332; P:cellular response to fructose stimulus; IEA:Ensembl.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0050892; P:intestinal absorption; IEA:Ensembl.
DR GO; GO:0051454; P:intracellular pH elevation; IEA:Ensembl.
DR GO; GO:0015797; P:mannitol transmembrane transport; IEA:Ensembl.
DR GO; GO:0046724; P:oxalic acid secretion; IEA:Ensembl.
DR GO; GO:2001150; P:positive regulation of dipeptide transmembrane transport; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IEA:Ensembl.
DR GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF113; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 90..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 170..193
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 242..266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 273..295
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 394..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 426..451
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 457..489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 513..723
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 594..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 81172 MW; 533EFD87D1549C8F CRC64;
MELQKQDYHV DRPLMNQEQL EELGRWDLTP RTYQWRTWLK CSHARARALL IQHLPVLGWL
PRYPVRDWLL GDLLSGLSVA IMQLPQGLAY ALLAGLPPVF GLYSSFYPVF IYFLFGTSRH
ISVGTFAVMS VMVGSVTESL APDENFLLDS NSTVNETARD VTRVQLASTL SVLVGLFQVG
LGLVHFGFVV TYLSEPLVRS YTTAASVQVF VSQLKYVFGL QLSSHSGPLS LIYIVLEVCW
KLPQSVIGTV ITALVAGVVL VMVKLLNDKL QRYLPLPIPG ELLTLIGATG ISYGVGLKQR
FGVDVVGNIP AGLVSPEAPN PQLFVKLVGN AFAIAVVGFA IAISLGKIFA LRHGYRVDSN
QELVALGLSN LIGGIFQCFP VSCSMSRSLV QESTGGNTQV AGAVSSLFIL LIILKLGELF
QDLPRAVLAA TIIVNLKGML MQFADICSLW KKNRVDLLIW LVTFVATILL NLDLGLAVAL
AFSLLLVVVR TQLPHYSVLG QVSDTDIYRD VAEYSDAREV PGVKIFRSSA TIYFANAELY
SDTLKQRCGV DVDHLISRKK KLLKKQEMKL KRLQKHKSPQ EQAVSSQDNS VSINVNTNLG
DIKSNDVESS KTKARPENEL EEIVASGQED AKAIAVPTLK ALGLPQPDFH SLILDLGALS
FVDTVCIKNL KNIFRDFREI EVDVYIAACH SPVVTQLEAG QFFDASITKR HLFVSVHDAV
TFALQHSKSG PISPVLATKL
//