ID I3N324_ICTTR Unreviewed; 641 AA.
AC I3N324;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=GRAM domain containing 4 {ECO:0000313|Ensembl:ENSSTOP00000018770.2};
GN Name=GRAMD4 {ECO:0000313|Ensembl:ENSSTOP00000018770.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018770.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000018770.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01080722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01080731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N324; -.
DR STRING; 43179.ENSSTOP00000018770; -.
DR Ensembl; ENSSTOT00000026313.2; ENSSTOP00000018770.2; ENSSTOG00000026193.2.
DR eggNOG; ENOG502QPMR; Eukaryota.
DR GeneTree; ENSGT00390000010968; -.
DR HOGENOM; CLU_028241_0_0_1; -.
DR InParanoid; I3N324; -.
DR TreeFam; TF320445; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0034164; P:negative regulation of toll-like receptor 9 signaling pathway; IEA:Ensembl.
DR CDD; cd13221; PH-GRAM_GRAMDC4; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037847; GRAMDC4.
DR InterPro; IPR037845; GRAMDC4_PH-GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR37402; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR37402:SF1; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 508..586
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
FT REGION 192..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 141..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 200..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 73226 MW; 6CBDDA3EF4ED9AB6 CRC64;
MWGGCGSPSW VVGLRWQAVG STGESREAWH RPWGPGLVTG EEPARHVQVR QRRSVLNMLR
RLDKIRFRGH KREDFLDLAE SPNASDTECG DELPLKIPRT SPRDSEELRD PAAPGTLIMA
SGVQDFNRTE FDRLNEIKGH LEIALLEKHF LQEELRKLRE ETNSEMLRQE LERERQRRIE
LEQKMQEVLK ARAEEQPAQA QPTPRGQSQA NHGAGKPTNR RGQGLSSRLQ KWFYERFGEY
VEDFRFQPEE STVETEEPLS ARRLTENMRR LKRGAKPVTN FVKNLSALSD WYSVYTSAIA
FTVYMNAVWH GWAIPMFLFL AILRLSLNYL IARGWRIQWS IVPEVSEAVE PPKEDLTVSE
KFQLVLDVAQ KAQNLFGKMA DILEKIKNLF MWVQPEITQK LYIALWAAFL ASCFFPYRLV
GLAVGLYAGV KFFLIDFIFK RCPRLRAKYD TPYIVWRSLP TDPQLKERAS ATMSRRLQTA
SSRSCVSSAP AGLGRDEDAG RCHSTKKGNF HEIFNLTENE RPLAVCENGW RCCLINRDRK
MPTDYIRNGV LYVTENYLCF ESSRSGSSKR NKVIKLVDIT DIQKYKVLSV LPGSGMGIAV
STPSTQKPLV FGAMVHRDEA FETIFSQYVK ITSAGASGGD S
//
