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Database: UniProt
Entry: I3N3E2_ICTTR
LinkDB: I3N3E2_ICTTR
Original site: I3N3E2_ICTTR 
ID   I3N3E2_ICTTR            Unreviewed;       471 AA.
AC   I3N3E2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-OCT-2019, entry version 46.
DE   RecName: Full=Protein C-ets-2 {ECO:0000256|PIRNR:PIRNR001698};
GN   Name=ETS2 {ECO:0000313|Ensembl:ENSSTOP00000018888};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000018888, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000018888}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000018888}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR001698,
CC       ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AGTP01030097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01030098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005323539.1; XM_005323482.2.
DR   STRING; 43179.ENSSTOP00000018888; -.
DR   Ensembl; ENSSTOT00000024663; ENSSTOP00000018888; ENSSTOG00000024655.
DR   GeneID; 101975209; -.
DR   CTD; 2114; -.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000160202; -.
DR   InParanoid; I3N3E2; -.
DR   OMA; RSWNSQS; -.
DR   OrthoDB; 526256at2759; -.
DR   TreeFam; TF316214; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001712; P:ectodermal cell fate commitment; IEA:Ensembl.
DR   GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016311; Transform_prot_C-ets.
DR   InterPro; IPR027276; Transform_prot_C-ets-2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF501032; C-ets-2; 1.
DR   PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   DNA-binding {ECO:0000256|PIRNR:PIRNR001698,
KW   ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Transcription {ECO:0000256|PIRNR:PIRNR001698};
KW   Transcription regulation {ECO:0000256|PIRNR:PIRNR001698}.
FT   DOMAIN       86    171       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      365    445       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      265    287       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   471 AA;  52861 MW;  AEB036FAEA7140EE CRC64;
     MNDFGIKNMD QVAPVANSFR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS
     HDSASCFELP LLTPCSKAVM SQALTATFSG FQKERRRLGI PKNPWLWSER QVCQWLLWAT
     SEFSLVNVNL QRLGMSGQVL CNLGKERFLE LAPDFVGDIL WEHLEQMIKE TQEKTEDQYE
     ENSHLNSVPH WINSNTLGFG VEQAPFSVQT QNYPKGGLLD SACPSSVAPG VLSSEQDFQM
     FPKSQLNTVS VNYCPVGQDF PGSNLNLLAS SSGKPEDRDS PETGADSFES ADSLLRSWSS
     QSSLLDVQRV PSFESFEDDC SQSLCLSKPT MSFKDYIQER SDPAEQGKPV IPAAVLAGFT
     GSGPIQLWQF LLELLSDKSC QSFISWTGDG WEFKLADPDE VARRWGKRKN KPKMNYEKLS
     RGLRYYYDKN IIHKTSGKRY VYRFVCDLQN LLGFTPEELH AILGVQPDTE D
//
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