ID I3N600_ICTTR Unreviewed; 740 AA.
AC I3N600;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=F-box and leucine rich repeat protein 18 {ECO:0000313|Ensembl:ENSSTOP00000019796.2};
GN Name=FBXL18 {ECO:0000313|Ensembl:ENSSTOP00000019796.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019796.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019796.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01104620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01104623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N600; -.
DR STRING; 43179.ENSSTOP00000019796; -.
DR Ensembl; ENSSTOT00000028100.2; ENSSTOP00000019796.2; ENSSTOG00000028236.2.
DR eggNOG; ENOG502QVW9; Eukaryota.
DR GeneTree; ENSGT00390000015109; -.
DR HOGENOM; CLU_021195_0_0_1; -.
DR InParanoid; I3N600; -.
DR TreeFam; TF331865; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR045627; FBXL18_LRR.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR12904; -; 1.
DR PANTHER; PTHR12904:SF23; FI05230P-RELATED; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF19729; FBXL18_LRR; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 55..96
FT /note="F-box"
FT /evidence="ECO:0000259|Pfam:PF12937"
FT DOMAIN 107..697
FT /note="F-box/LRR-repeat protein 18 LRR"
FT /evidence="ECO:0000259|Pfam:PF19729"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 81103 MW; 3902CB1536021708 CRC64;
RCVQPRPLPG LLSRGRAGFQ HPWRGRREAS DSGEDDVPPA AADVAGGAHL LGFSDEILLH
ILSHVPSIDL VLNVRHTCRK LAALCLDKSL VHTVLLQKDY QASEDKVKQL VKEIGQEIQQ
LNMAGCYWLS GSTIEHVARC RGLVKVNLSG CHLTSLRLSK VLSALQHLRS LAIDVSPGFD
ASQLSSECKA TLSRVRELKQ TLFTPSYGVV PCCASLQKLL LYFEILDRTR EGAVLSGQLM
VGQSNVPHYQ NLRVFYARLA PGYINQEVVR LYLAVLSDRT PENLHAFLIS VPGSFAESGA
TKNLLDSMAR NVALDALQLP KSWLNGSSLL QHMKFNNPFY FSFSRCTLSG GHLIQRVING
GKDLRSLASL NLSGCVHCLS PDSLLRKAED AIDSSILETL VAACCNLRHL NLSAAHHHSA
EGPGGHLCQL LARLRHLRSL SLPVCSVADA AAWADRVPVQ PVMRAVPRGF GKKVRIGVQT
CPSPFLGQAA PQPSSVFWSL LKNLPFLEHL ELIGSNFSSA MPRNEPAIRN SLPPCSRAQN
VGDSEVAAIG QLAFLRHLTL AQLPGILTGS GLVSIGLQCQ QLQSLSLANL GMMGKVVYMP
ALSDMLKHCR RLKDLRLEQP YFSANAQFFQ ALSQCSSLQR LCLVSRSGSL QPEAVLAFMA
RCPHVVVCHM FTGESLATCK NLQQSLLRSF QAERPALNVV IFPLLHEGLT DVIRDVPMVH
LDEITLFKSR VAEEPPNLWW
//
