ID I3N685_ICTTR Unreviewed; 357 AA.
AC I3N685;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Interferon regulatory factor 9 {ECO:0000313|Ensembl:ENSSTOP00000019881.2};
GN Name=IRF9 {ECO:0000313|Ensembl:ENSSTOP00000019881.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019881.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019881.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01099335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01099336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N685; -.
DR STRING; 43179.ENSSTOP00000019881; -.
DR Ensembl; ENSSTOT00000028058.2; ENSSTOP00000019881.2; ENSSTOG00000023450.2.
DR GeneTree; ENSGT00940000162115; -.
DR HOGENOM; CLU_031544_1_1_1; -.
DR InParanoid; I3N685; -.
DR TreeFam; TF328512; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0070721; C:ISGF3 complex; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF26; INTERFERON REGULATORY FACTOR 9; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 9..116
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 116..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 40349 MW; 699C8698AF70D670 CRC64;
MATGRARSTR KLRNWVVEQV ESGNFPGVCW DDTNKTMFRI PWKHAGKQDF REDQDAAFFK
AWAIFKGKSK EGDIGGPAVW KTRLRCALNK SPEFEEVPER GCMDVAEPYK VYRLLPPGTL
PAHPETQKSP SKRCHSSVSS EREEEEDTSN NCTLSPNYLQ DPLNNSQEGV DTTEATVQED
QVSMEHLPPL NSDYSLLLTF IYSGRVVGKA QVHSLDCRLV AEFSDSRSSM EQVVFPKPDP
SEPIQRLLSQ IERGILVASN SRGLFVQRLC PIPISWNAPQ APPGPGPHLL PSNKCVELFR
TTYFCRDLDR YSQGLGPLPK FQVALHFWER SSDPNNTSQN LITVQMEQAF ARHLLEK
//
