ID   I3N6W8_ICTTR            Unreviewed;       933 AA.
AC   I3N6W8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSSTOP00000020114.2};
GN   Name=ARHGEF10 {ECO:0000313|Ensembl:ENSSTOP00000020114.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020114.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000020114.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AGTP01077006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01077007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01077008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01077009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01077010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3N6W8; -.
DR   STRING; 43179.ENSSTOP00000020114; -.
DR   Ensembl; ENSSTOT00000020494.2; ENSSTOP00000020114.2; ENSSTOG00000020506.2.
DR   eggNOG; KOG3522; Eukaryota.
DR   GeneTree; ENSGT00940000153798; -.
DR   HOGENOM; CLU_001213_1_0_1; -.
DR   InParanoid; I3N6W8; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR   GO; GO:0051298; P:centrosome duplication; IEA:Ensembl.
DR   GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR   GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          69..256
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          786..826
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          841..894
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        786..811
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..863
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   933 AA;  103728 MW;  E5D8F2FD271B83A5 CRC64;
     AREGTKDGLE KTRAAVKRGR SFIRTKSLLS QDHRSGLDEE QSLFIDVDCK HPEAVLTPMP
     EGLSQQQVVR RYILGSIVES EKNYVDALKR ILEQYEKPLS ETEPRLLSDR KRKVVFYRVR
     EILQCHSMFQ IALASRVSEW DAVETIGDVF VASFSKSMVL DAYSEYVNNF STAVAVLKKT
     CAAKPAFLEF LKQSQESSPD RVTLYSLMMK PIQRFPQFIL LLQDMLKNTS KGHPDRLPLQ
     MALTELETLA EKLNERKRDA DQRCEIRQIA KAVNERYLDK LLSSGSRYLI RSDDVIETVY
     NDRGEVVKTK ERRLFMLNDV LMCATASPRT SQESRFPASQ RYLLKWSVPL GHTDVIQYGP
     GTGHQGRCPT THAPESLAVV PNAKPHKVYM GPGQLYQDLQ NLLHDLNVVG QIAQLIGNLK
     GSYQNLNQSV AHDWTSGLQR LILKKEEEIR AADRCRIQLQ LPGKQDKSGR PTFFTAVFNT
     FTPAIKESWV NNLQMAKLAL EEENHLGWFC VDDEGSHTKK ETHPLLVGHM PVTVARQPEF
     KIGSCSDQMG QIAIVSFHNS TPKVIECFNV ESRILCMGYI PAEEQQREPS TIVDPEAQAT
     RASEVPTICV GTEEGGSWNS EPQKVIRLGV LPVRSLLLME DTLWAASGGQ VFLISTETHA
     VESQLEAHHE EGMVISHMAV AGVGIWIAFT SGSTLRLFHT ETLKHLQDVN ITAPVHSVLP
     GHQRLSVTSL LVCHGLLMVG TSLGVVVALP VPRLQGIPKV TGRGMVSYHA HHGPVKFIVM
     ATALHKKDQD QARDSPPPGL EPQEEDQRDV LPTEGTGASP SPGDLDTAIW LADSWGPVNH
     KSDLSSSSGS LSLSQGSSSL EHRSEDSSTC DLLKDPTAPP RSRARRPRKA KASSVLVVCG
     GQGHRRVCRK GRQQPPEEMV SSVMVWQIPL LSA
//