ID I3N712_ICTTR Unreviewed; 566 AA.
AC I3N712;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Adhesion G protein-coupled receptor A1 {ECO:0000313|Ensembl:ENSSTOP00000020158.2};
GN Name=ADGRA1 {ECO:0000313|Ensembl:ENSSTOP00000020158.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020158.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020158.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGTP01019164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01019165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01019166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3N712; -.
DR STRING; 43179.ENSSTOP00000020158; -.
DR Ensembl; ENSSTOT00000024420.2; ENSSTOP00000020158.2; ENSSTOG00000022466.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160175; -.
DR HOGENOM; CLU_020720_1_0_1; -.
DR InParanoid; I3N712; -.
DR OrthoDB; 2900279at2759; -.
DR TreeFam; TF331206; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45930:SF3; ADHESION G PROTEIN-COUPLED RECEPTOR A1; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..312
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 213..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 61857 MW; 1B801BAB24382CA4 CRC64;
MDLKTVLSLP RFPGEFLHPV VYACTAVMLL CLLASAVTYI VHRSAIRISR KGRHTLLNFC
FHAALTFTVF AGGINRTKHP ILCQGVGILL HYSTLSTMLW VGVTARNIYK QVTKKALPCP
GADQLPYPKQ PLLRFYLISG GVPFVICGVT AATNIRNYGT EDEDAAYCWM AWEPSLGAFY
GPAALVVLVT CVYFLGTYIQ LRRHPERRYE LRERSEEQQR LAVPEGGHRH GAQPCTTPAC
DPLAASQLQN EHSFKAQLRA AAFTLFLFMA TWAFGALAVS QGHFLDMVFS CLYGAFCVTL
GLFVLIHHCA KREDVWQCWW SCCPSRGDVP QQPSTHPTLE ANGDVLGHMA CLQDSPCPGQ
ARGFSHPAPG HCKMTNLQAA QGHASCLSPA TPCCAKMHCE QLMEDEAHGH LPEGEAFLHE
PHLHRCLEGR TKPHYFHPAA SAPREYAYHV PSSLDGSPHS SRTDSPPSSL EGPMGVHTLA
CCTPGDPFPM VSQPEGSDAS SALYGCPPRL PPGPAHLEML RRTQSLPFGS PGQNGLLKGD
LREGLPFGTD GTGNIRTGPW KNETTV
//
