ID I3N843_ICTTR Unreviewed; 1744 AA.
AC I3N843;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=ADAMTS like 1 {ECO:0000313|Ensembl:ENSSTOP00000020539.1};
GN Name=ADAMTSL1 {ECO:0000313|Ensembl:ENSSTOP00000020539.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000020539.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000020539.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGTP01086624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01086633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000029607.2; ENSSTOP00000020539.1; ENSSTOG00000019570.2.
DR eggNOG; KOG3538; Eukaryota.
DR eggNOG; KOG4597; Eukaryota.
DR GeneTree; ENSGT00940000156243; -.
DR HOGENOM; CLU_001717_1_0_1; -.
DR OMA; VECVHIR; -.
DR TreeFam; TF351125; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 11.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF157; ADAMTS-LIKE PROTEIN 1; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 11.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00209; TSP1; 13.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 12.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 10.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1744
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003677666"
FT DOMAIN 844..932
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1146..1248
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1268..1351
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1377..1467
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1708..1744
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 975..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 45..76
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 49..81
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 60..66
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 1744 AA; 191688 MW; FD4A35A7EBCC3C25 CRC64;
MECCRRATPG IPLLLLAFLL LSSRAARSEE DRDGLWDAWG PWSECSRTCG GGASYSLRRC
LSSKSCEGRN IRYRTCSNVD CPPEAGDFRA QQCSAHNDVK HHGQFYEWLP VSNDPDNPCS
LKCQAKGTTL VVELAPKVLD GTRCYTESLD MCISGLCQIV GCDHQLGSTA KEDNCGVCNG
DGSTCRLVRG QYKSQLSATK LDDTVVAIPY GSRHIRLVLK GPDHLYLETK TLQGAKGENS
LSSTGTFLVD NSTVDFQKFP DKEILRMAGP LTADFIVKIR DSGPTDSTVQ FIFYQPIIHR
WRETDFFPCS ATCGGGYQLT SAECYDLRSN RVVADQYCHY YPENIKPKPK LQECNLDPCP
ARWEATPWTA CSSSCGGGIQ SRAVSCVEED IQGHVTSVEE WKCMYTPKMP IVQPCNIFDC
PKWLAQEWSP CTVTCGQGLR YRVVLCIDHR GMHTGGCSPK TKPHIKEECI IPTPCYKPKE
KLPVEAKLPW YKQAQELEEG AAVSEEPSFI PEAWSACTVT CGMGTQVRVV KCQVLLSFSQ
SVADLPVDEC EGPKPASQRA CYAGPCNGEI PEFNLDSTDG LLGGLQDLDE LYDWEYEGFT
KCSESCGGGV QEAVVSCLNK QTRELADENL CVTSRRPPQL LKSCNLDPCP ARWEIGKWSP
CSLTCGVGLQ TRDVFCSHLL SRELNEMVIL ADDLCRHPKP STVQACNRFN CPPAWYPAQW
QPCSRTCGGG VQKREVLCKQ RMADGSFLEL PETFCSASKP TSQQACKKED CPSEWLLSDW
TECSTSCGEG TQTRSAICRK VLKTGVSTVV NSTLCPPLPF SSSIRPCMLA TCARPGRPST
KHSPHIAAAR NVYIQTRRQR KLHFVVGGFA YLLPKTAVVL RCPTRRFRKP LITWEKDGQH
LISSAHITVA PFGYLKIHRL RPSDAGIYTC SAGPAREQFV IKLIGGNHKL VARPLSLRSE
EEALAVRKVS PKEALQTHKH QNGIFANGSK AEKRGLPADP GSRYDDIVSR LLEQGGWPGE
LLTSWEVQDS MERNTSSEED PNAEQALLHL PFTMVTEQKR LDDILRNLSQ QPEELRDLYG
KHLVAQLAQD IFRSHLEHQD MLLKPSEQRF PPVAIPPHKH VSGFSSSLRT SSGEAGGGSR
RPHRKPTILR KISAAQQLSA SEVVTHLGQT VALASGTLSV LLHCEAIGNP RPTISWARNG
EEVQFSDRIL LQPDDSLQIL APVEADVGFY TCNATNALGY DSVSIAVTLA GKPLVKTSRM
TVVNTEKPAV TVDVGSTVKT VQGANVTINC QVAGVPEAEV TWFRNKSKLG SSHHLHEGSL
LLTNVSSLDQ GLYSCRAANV HGELTENTQL LILDPPHVPT QLEDIKALLS ATGPNLPSVL
TSPLGTQLVL DPGNSALLGC PIKGYPTPNI TWFHGGQPIA TTTGLTHHIL ASGQILQVAN
LSGGSQGEFS CLAQNEAGML MQKASLVIQD YWWSVDRLVT CSASCGNRGV QQPRLRCLLN
NTEVDPAHCA GKARPAVQPI ACNRRDCPSR WMVTSWSACT RSCGGGIQTR RVTCQKLKAS
GISTPVSNDM CTQLAKRPVD TQACNQQLCV EWAFSNWGQC NGPCIGPRLA VQHRQVFCQT
RDGITLPSEQ CSALPRPVST QNCWSDACSV HWRVSLWTLC TATCGNYGFQ SRRVECVHAR
TNKAVPEHLC SWGPRPANWQ RCNITPCENM ECRDTTRYCE KVKQLKLCQL SQFKSRCCGT
CGKA
//
