ID I3NAA0_ICTTR Unreviewed; 2237 AA.
AC I3NAA0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Protein tyrosine phosphatase receptor type Q {ECO:0000313|Ensembl:ENSSTOP00000021297.2};
GN Name=PTPRQ {ECO:0000313|Ensembl:ENSSTOP00000021297.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021297.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021297.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01095780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01095789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 43179.ENSSTOP00000021297; -.
DR Ensembl; ENSSTOT00000025319.2; ENSSTOP00000021297.2; ENSSTOG00000024058.2.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000159215; -.
DR HOGENOM; CLU_410270_0_0_1; -.
DR InParanoid; I3NAA0; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032421; C:stereocilium bundle; IEA:Ensembl.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0060116; P:vestibular receptor cell morphogenesis; IEA:Ensembl.
DR CDD; cd00063; FN3; 14.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR Pfam; PF00041; fn3; 12.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 16.
DR SMART; SM00194; PTPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 8.
DR PROSITE; PS50853; FN3; 14.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..2237
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012203956"
FT TRANSMEM 1893..1915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..154
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 158..253
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 309..397
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 569..664
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 669..758
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 763..853
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 858..947
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 952..1052
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1057..1149
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1151..1244
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1302..1424
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1329..1415
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1419..1523
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1528..1626
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1631..1732
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1990..2210
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT REGION 230..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2237 AA; 250613 MW; F9EDDF696E45ECE2 CRC64;
MDFLIIFLLF FIGTSETQVD VSDAVPNTRY DTTISSISAA TYSSPVSRTV TTNVTKPGPP
VFLAGERVGS AGILLSWNTP PNPNGRIISY IVKYKEVCPW MQTVYTQVRA KPDSLEVLLT
NLNPGTTYEI KVAAENSAGI GVFSDPFLFQ TAESAPGKVV NLTVEAFNYS AVNLIWYLPR
QPNGRITSFK ISVKHARSGT VVKDVSVRVE DILTGKLPEC NENSDSFLWS TSSPSPTLGR
VTPPQRTTYT SSSLTRSRIS SVWKEPISFV VTHLRPYTTY LFEVSAVTTE AGYIDSTIVR
TPESVPEGPP QNCIAGNVTG KSFSISWDPP SVVTGKFSYR VELYGVSGRI LDNSTKDLKF
SFTNLTPYTL YDVYVAAETS AGVGPKSNLS IFTPPDVPGA IFDLQLADVE ATEIRITWRK
PRQPNGIINQ YRVKVLVSET GVVLENTLLT GKDEYINDPM SPEMMNIVEP MIGFYEGSAE
MSSDLHSLAS FVYNNDVHNN FLVRSRAEDQ HSPVVTTRNQ YITDIAAEQL SYVIRRLAPF
TEHMISVSAF TIMGEGPPTV LNVRTREQVP SSIQTINYKN ISSSSILLYW DPPEYPNGKI
THYTIYAMEL DTNRAFQMTT IDNSFLITGL KKYTKYKMRV AASTHVGESS LSEENEIFVR
TPEDEPESSP QDVEVIDVSA SEIRLKWSPP EKPNGIIVAY EVLYKNMDTL RIKNTSTTSI
TLRDLKPYTL YNISVRSYTK FGHGNQSSAL LSVRTSETVP SSAPENITYK NISSEEIEIS
FLPPHSPNGI IQKYTIYLKR SNGNEEKSIN TTSLTQNIKG LKKYTQYVIE MSASTLKGEG
VRSAPIGILT EEDAPDSPPQ DFSVKQLSGV TVKLSWKPPL EPNGIILYYT VYVWDISSLK
TINVTGTSLE FSDLDYNVEY SAYVTASTRF GDGKTRSKII NFRTPEGAPS DPPRDVHYVN
LSSSSIILFW TPPSKPNGII QYYSVYYRNT SGTFIRNFTL YEVTNDFDNM TVSAIIDKLA
IFSYYTFWLT ASTSFGNGNK TSDIIQVYTD QDIPEGLVGN LTYQSISSTA INVSWVPPSH
PNGLVFYYVS LNIQQSPRHG KPPLVTYDSS IYFDNLEKYT DYILEITPST EKGFSDIYTA
QLLIKTEEDV PETSPIINTF KNLSSTSVLL SWDPPVKPNG AIISYDLILQ GPNENYSFIT
SDNYIILEEL SPFTLYSFFA AARTVKGLGP PSILFFYTDE SVPLAPPQNL TLINYTSDFV
WLKWSPSPLP GGIVKIYSLK IHEHESDTIS YKFTTSTFLP LPSFHSIVNN NFQNHSQWNL
IDLIQDQYVV QNLQCMASNW QSVLVTWDPP KKANGIITHY IIMVERNSTK ASPQNHTYTF
VKLLANTSYV FKIRAATSAG EGSESTCSVS TPPETVPSAP TNIAFSDVQS TTATLTWIRP
DSILGYFQNY KITTQLRAQE CREWQSEECV EYQKVQYLYE ADLTEETVYG LKKFRWYRFQ
VSASTNAGYG NASNWISTQT LPGPPDGPPE NVHVVATSPF SINISWSEPA VITGPTFYLI
DVKSVDRDEF NISFVKSNEE NKTMEIKDLK IFTRYSVVIT AFTGNVSAAY IEGKSSPEVI
VTTLESAPKD PPNNMTFQKI PDEVTKFQLT FLPPSQPNGN IQVYQALVYR EDDPTAVQIH
NLSIIQKTDT SVIAMLEGLK GGHTYNISVY AINSAGAGPK VQMRITMDIK APARPKTKPT
PIYDATGKLL VTSTTITIRM PICYYNDDHG PIKSVQVLVA ETGAQHDGNV TKWYDAYFNK
ARPYFTNEGF PNPPCIEGKT KFSGNEEIYV IGADNACMIP GNEDKICNGP LKPKKQYLFK
FRATNVMGQF TDSDYSDPIK TLGEGLSERT VEVILSVTLC ILSIILLGTA IFAFARIRQK
QKEGGTYSPR DAEIIDTKFK LDQLITVADL ELKDERLTRL LSYRKSIKPI SKKSFLQHVE
ELCTNNNLKF QEEFSELPKF LQDLSSTDAD LPWNRAKNRF PNIKPYNNNR VKLVADASIP
GSDYINASYV SGYLCPNEFI ATQGPLPGTV GDFWRMVWET RAKTLVMLTQ CFEKGRIRCH
QYWPEDNKPV TVFGDIVITK LMEDVQINWT IRDLKIERHG DYMTVRQCNF TGWPEHGVPE
NSTPLIHFVK LVRASRAHDT TPMIAQYIFL HQCILDLLSN KGSNQPICFV NYSALQKMDS
LDAMEGDVEL EWEETTM
//
