ID I3NBI2_ICTTR Unreviewed; 370 AA.
AC I3NBI2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Lysophosphatidylglycerol acyltransferase 1 {ECO:0000313|Ensembl:ENSSTOP00000021729.2};
GN Name=LPGAT1 {ECO:0000313|Ensembl:ENSSTOP00000021729.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021729.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021729.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 1-acyl-sn-glycerol-3-phosphate
CC acyltransferase family. {ECO:0000256|ARBA:ARBA00008655}.
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DR EMBL; AGTP01057985; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01057986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01057987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01057988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01057989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NBI2; -.
DR STRING; 43179.ENSSTOP00000021729; -.
DR Ensembl; ENSSTOT00000019598.2; ENSSTOP00000021729.2; ENSSTOG00000019588.2.
DR eggNOG; KOG1505; Eukaryota.
DR GeneTree; ENSGT00950000182836; -.
DR HOGENOM; CLU_046804_1_0_1; -.
DR InParanoid; I3NBI2; -.
DR TreeFam; TF314346; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0047190; F:2-acylglycerophosphocholine O-acyltransferase activity; IEA:Ensembl.
DR GO; GO:0071617; F:lysophospholipid acyltransferase activity; IEA:Ensembl.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR CDD; cd07990; LPLAT_LCLAT1-like; 1.
DR InterPro; IPR032098; Acyltransf_C.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR10983; 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR10983:SF2; ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1; 1.
DR Pfam; PF16076; Acyltransf_C; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR SMART; SM00563; PlsC; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..219
FT /note="Phospholipid/glycerol acyltransferase"
FT /evidence="ECO:0000259|SMART:SM00563"
SQ SEQUENCE 370 AA; 43154 MW; 872788216BACD2DC CRC64;
MAATLEEVPR RGWILVKALM RFAFMIFNNL VAIPSYVCYV IVLQPLRALD SKRFWYIEGT
MYKWLLGMVA SWGWFAGYTV MEWGEDIKAI SEDEAMMLVN HQATGDVCTL MMCLQDKGRA
VAQLIWLMDH IFKYTNFGIV SLIHGDFFIR QGKSHRDQQL LLLKKHLENN YRSRDRKWIV
LFPEGGFLRK RRETSQAYAK KNNLPFLTHV TLPRFGATKI ILSVLVARQE NGSQAGGDAK
ELESKSKGLQ WIIDTTIAYP KAEPLDIQTW ILGYRKPTVT HVHYRIFPVK DVPLETDDLA
NWLYQRFIEK EDLLSHFYKT GAFPPVKGQK EAVSREMNLS NTWLFLIYSF AVLSACMWYN
IIEYFYHCLF
//
