ID   I3NBQ9_ICTTR            Unreviewed;       415 AA.
AC   I3NBQ9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN   Name=TRAF1 {ECO:0000313|Ensembl:ENSSTOP00000021806.1};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021806.1, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000021806.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR015614}.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC       {ECO:0000256|PIRNR:PIRNR015614}.
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DR   EMBL; AGTP01019791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005320964.1; XM_005320907.2.
DR   RefSeq; XP_013212068.1; XM_013356614.1.
DR   AlphaFoldDB; I3NBQ9; -.
DR   STRING; 43179.ENSSTOP00000021806; -.
DR   Ensembl; ENSSTOT00000025318.2; ENSSTOP00000021806.1; ENSSTOG00000023272.2.
DR   eggNOG; KOG0297; Eukaryota.
DR   GeneTree; ENSGT00940000161076; -.
DR   HOGENOM; CLU_021061_0_0_1; -.
DR   InParanoid; I3NBQ9; -.
DR   OMA; CIVETNA; -.
DR   OrthoDB; 2913784at2759; -.
DR   TreeFam; TF321154; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
DR   GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:UniProt.
DR   GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   CDD; cd03779; MATH_TRAF1; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR037306; TRAF1_MATH.
DR   InterPro; IPR032070; TRAF_BIRC3-bd.
DR   InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR   PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR   PANTHER; PTHR10131:SF96; TNF RECEPTOR-ASSOCIATED FACTOR 1; 1.
DR   Pfam; PF21355; TRAF-mep_MATH; 1.
DR   Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR   PIRSF; PIRSF015614; TRAF; 2.
DR   SMART; SM00061; MATH; 1.
DR   SUPFAM; SSF49599; TRAF domain-like; 1.
DR   PROSITE; PS50144; MATH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR015614};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR015614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Zinc {ECO:0000256|PIRNR:PIRNR015614}.
FT   DOMAIN          265..411
FT                   /note="MATH"
FT                   /evidence="ECO:0000259|PROSITE:PS50144"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          186..262
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   415 AA;  45846 MW;  B2772A2F0D2E3F3D CRC64;
     MASNSASSPH QAPDENEFPF GCPRTVRQDP PEPRALCCTA CLSENLRNSP DGICPKCRGD
     SLQSESPRSL LTQEKVHPEV AKAGVGCPFG AIGCSFKGSP QAVQEHEASS SASHLSLLLG
     FVKHCKAQLG PGLGSGPMAL EQNLSDLQLQ AAVEVAGDLE VDCYRAPCSE SQEELALQHF
     LKEKLLAELE EKLRVFENIV AVLNKEVEAS HLALAASLHQ SQLDREHILS LEQRVVELQQ
     TLAQKDQALG KLEQSLRLME EASYDGTFLW KITNVARRCH ESACGRTISL FSPAFYTAKY
     GYKLCLRLYL NGDGTGKRTH LSLFIVIMRG EYDALLSWPF RNKVTFMLLD QNNREHAIDA
     FRPDLSSASF QRPQSETNVA SGCPLFFPLN RLHSPKHAYV KDDTMFLKCI VETSA
//