ID I3NBY0_ICTTR Unreviewed; 326 AA.
AC I3NBY0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Docking protein 4 {ECO:0000313|Ensembl:ENSSTOP00000021877.1};
GN Name=DOK4 {ECO:0000313|Ensembl:ENSSTOP00000021877.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000021877.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000021877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOK family. Type B subfamily.
CC {ECO:0000256|ARBA:ARBA00006520}.
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DR EMBL; AGTP01009404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005318284.1; XM_005318227.1.
DR AlphaFoldDB; I3NBY0; -.
DR STRING; 43179.ENSSTOP00000021877; -.
DR Ensembl; ENSSTOT00000020799.2; ENSSTOP00000021877.1; ENSSTOG00000023553.2.
DR GeneID; 101957775; -.
DR CTD; 55715; -.
DR eggNOG; KOG4047; Eukaryota.
DR GeneTree; ENSGT00940000160143; -.
DR HOGENOM; CLU_057256_1_0_1; -.
DR InParanoid; I3NBY0; -.
DR OMA; KMLSIEC; -.
DR OrthoDB; 2996885at2759; -.
DR TreeFam; TF324994; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl.
DR CDD; cd14678; PH_DOK4_DOK5_DOK6; 1.
DR CDD; cd13164; PTB_DOK4_DOK5_DOK6; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037816; DOK4/5/6_PH.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258:SF44; DOCKING PROTEIN 4; 1.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 132..237
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
SQ SEQUENCE 326 AA; 37044 MW; D0766AEA0E9263AF CRC64;
MATNFNDIVK QGYVKMKSRK LGIYRRCWLV FRKSSSKGPQ RLEKYPDEKS VCLRGCPKVT
EISNVKCVTR LPKETKRQAV AIIFTDDSAR TFTCDSELEA EEWYKTLSVE CLGSRLNDIS
LGEPDLLAPG VQCEQTDRFN VFLLPCPNLD VYGECKLQIT HENIYLWDTH NPRVKLVSWP
LCSLRRYGRD ATRFTFEAGR MCDAGEGLYT FQTQEGEQIY QRVHSATLAI AEQHKRVLLE
MEKNVRLLNK GTEHYSYPCT PTTMLPRSAY WHHITGSQNI AEASSYAGEG YGAAQASSET
DLLDRFILLK PKPSQGDSSE AKTPSQ
//
