ID I3NCX9_ICTTR Unreviewed; 338 AA.
AC I3NCX9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=STEAP family member 1 {ECO:0000313|Ensembl:ENSSTOP00000022226.2};
GN Name=Steap1 {ECO:0000313|Ensembl:ENSSTOP00000022226.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022226.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022226.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the STEAP family.
CC {ECO:0000256|ARBA:ARBA00007729}.
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DR EMBL; AGTP01078545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005334745.1; XM_005334688.1.
DR AlphaFoldDB; I3NCX9; -.
DR STRING; 43179.ENSSTOP00000022226; -.
DR Ensembl; ENSSTOT00000025543.2; ENSSTOP00000022226.2; ENSSTOG00000023808.2.
DR GeneID; 101958701; -.
DR CTD; 26872; -.
DR eggNOG; ENOG502QWI9; Eukaryota.
DR GeneTree; ENSGT00390000008042; -.
DR HOGENOM; CLU_034618_0_0_1; -.
DR InParanoid; I3NCX9; -.
DR OrthoDB; 5361at2759; -.
DR TreeFam; TF332031; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR PANTHER; PTHR14239; DUDULIN-RELATED; 1.
DR PANTHER; PTHR14239:SF3; METALLOREDUCTASE STEAP1-RELATED; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..253
FT /note="Ferric oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01794"
SQ SEQUENCE 338 AA; 39766 MW; 859B3F0DE258FA28 CRC64;
MDTRKDTTNQ ELWKTKPRKN LEDDDFLTKD TGETSMLKRP VLLHLQQTAH VDEFDCPSEL
QHKQELFPKW RLPIKIAAII SSLTFLYTLL REIIHPLVTD HQQYFYRIPI LVINKVLPVV
SITLLALVYL PGVIAAIVQL RNGTKYKKFP PWLDRWMLTR KQFGLLSFFF AVLHAIYSLS
YPMRRSYRYK LLKWAYQQVK QNKEDAWIEH DVWRMEIYVS LGIVGLAILT LLAVTSIPSV
SDSLTWREFR YIQSKLGIVS LLLGTIHALI FAWNKWVDIK QFVWYTPPTF MIAVFLPIVV
LICKTVLFLP CLRKKILKIR RGWEDVTKIN KTEMSSQL
//