ID I3ND28_ICTTR Unreviewed; 464 AA.
AC I3ND28;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Tapasin {ECO:0000256|ARBA:ARBA00039535};
DE AltName: Full=TAP-binding protein {ECO:0000256|ARBA:ARBA00041647};
GN Name=TAPBP {ECO:0000313|Ensembl:ENSSTOP00000022275.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022275.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022275.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the association of MHC class I with transporter
CC associated with antigen processing (TAP) and in the assembly of MHC
CC class I with peptide (peptide loading).
CC {ECO:0000256|ARBA:ARBA00037757}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AGTP01011068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3ND28; -.
DR STRING; 43179.ENSSTOP00000022275; -.
DR Ensembl; ENSSTOT00000024381.2; ENSSTOP00000022275.2; ENSSTOG00000025004.2.
DR eggNOG; ENOG502QR0A; Eukaryota.
DR GeneTree; ENSGT00940000159200; -.
DR HOGENOM; CLU_043155_0_0_1; -.
DR InParanoid; I3ND28; -.
DR TreeFam; TF334274; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0061779; C:Tapasin-ERp57 complex; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0044183; F:protein folding chaperone; IEA:Ensembl.
DR GO; GO:0062061; F:TAP complex binding; IEA:Ensembl.
DR GO; GO:0046978; F:TAP1 binding; IEA:Ensembl.
DR GO; GO:0046979; F:TAP2 binding; IEA:Ensembl.
DR GO; GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; IEA:InterPro.
DR GO; GO:0002398; P:MHC class Ib protein complex assembly; IEA:Ensembl.
DR GO; GO:0002502; P:peptide antigen assembly with MHC class I protein complex; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0061635; P:regulation of protein complex stability; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR008056; Tapasin.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR PANTHER; PTHR23411:SF22; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 1.
DR PRINTS; PR01669; TAPASIN.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..464
FT /note="Tapasin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012700513"
FT DOMAIN 292..399
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 464 AA; 49557 MW; BA3D3FC45B15CDFA CRC64;
MKPLSLLLAV TLGLATTVSA GPSAIECWFV EDVGGGGLAK RPAALLLRQG PEGPPPRPDL
DPKLYLKVDD PTGTLQAAFR RYPRGVPAPH CEISRYIPLP ASANWASGLT PERSCPRALD
GAWLTVSMSS SVLSLSSLLR LQPEPQQEPV LITVATVVLT VLTHTPAPRI RLGQDAILDL
SFAYMPPTLE ATASLAPSPP PFGLEWRRQH LGKGHLLLAA TPGLGGQMPA AREGAVAFAA
WDDDDPWGPW TGNGTFWLPA VRPFQEGTYL ATVHLPYLQG QVSLELTMHK PPKVSLSPAP
LVWAAPGEAP PELQCLVSHF YPSEGLEVEW EFRGGSESGS QKAEGQRWLS SLRHHSDGSV
SLSGHLQLPP ITAEQHGARY ICRVHHSSLP ASGRSAEVTV EVAGFSGPSL EDGVGLFLSA
FLLLGLFKVL GWVGECDTIP TMGRTGARHH SSALPLYIPT SQPS
//
