ID I3NEE5_ICTTR Unreviewed; 449 AA.
AC I3NEE5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Fatty acid desaturase 3 {ECO:0000313|Ensembl:ENSSTOP00000022742.1};
GN Name=FADS3 {ECO:0000313|Ensembl:ENSSTOP00000022742.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022742.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022742.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005105}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
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DR EMBL; AGTP01066762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01066763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005331565.1; XM_005331508.1.
DR AlphaFoldDB; I3NEE5; -.
DR STRING; 43179.ENSSTOP00000022742; -.
DR Ensembl; ENSSTOT00000021259.2; ENSSTOP00000022742.1; ENSSTOG00000019661.2.
DR GeneID; 101970181; -.
DR CTD; 3995; -.
DR eggNOG; KOG4232; Eukaryota.
DR GeneTree; ENSGT00950000182990; -.
DR HOGENOM; CLU_016265_0_1_1; -.
DR InParanoid; I3NEE5; -.
DR OMA; FGGMQYQ; -.
DR OrthoDB; 294339at2759; -.
DR TreeFam; TF313604; -.
DR UniPathway; UPA00658; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR PANTHER; PTHR19353:SF11; FATTY ACID DESATURASE 3; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..101
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 51570 MW; C81DAF868912D3A4 CRC64;
MGGVGEPGGE PGPREGPAQP GAPLPVYRWE QIRKHDLPGD KWLVIERRVY DISRWAQRHP
GGSRLIGHHG AEDATDAFRA FHQDLNFVRK FLQPLLIGEL APEEPSQDGP QNVQLIEDFR
ALRQAAEDMK LFEADPTFFA LLLGHILAME VLAWLIVYLL GPGWVPSTLA ALILAVSQAQ
CWCLQHDLGH ASIFRKSRWN HVAQQFVMGQ LKGFSAHWWN FRHFQHHAKP NIFHKDPDVT
VAPVFLLGES SVEYGKKKRR YLPYNHQHLY FFLIGPPLLT LVNFEVENLA YMLVCLQWTD
LLWAASFYSR FFLSYVPFYG VPGALLLFVA VRVLESHWFV WITQMNHIPK EIGHEKHRDW
ASSQLAATCN VEPSLFIDWF SGHLNFQIEH HLFPTMPRHN YRRVAPLVKA LCAKHGLHYE
VKPFLTALLD IVGSLKKSGD IWLDAYLHQ
//
