ID I3NEU0_ICTTR Unreviewed; 1228 AA.
AC I3NEU0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Insulin receptor substrate 4 {ECO:0000313|Ensembl:ENSSTOP00000022887.2};
GN Name=IRS4 {ECO:0000313|Ensembl:ENSSTOP00000022887.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000022887.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000022887.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01029689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NEU0; -.
DR STRING; 43179.ENSSTOP00000022887; -.
DR Ensembl; ENSSTOT00000023407.2; ENSSTOP00000022887.2; ENSSTOG00000021221.2.
DR eggNOG; ENOG502SD84; Eukaryota.
DR GeneTree; ENSGT00940000160883; -.
DR HOGENOM; CLU_290952_0_0_1; -.
DR InParanoid; I3NEU0; -.
DR TreeFam; TF325994; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 78..199
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 231..335
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 55..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..623
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 130616 MW; BBA23AACAB310D8D CRC64;
MASSSFARDQ ATRRLRAAAA AAAAALAAVT TTPLLSSGTP TALIGTGSSC PGAMWLSTAT
GSRSDSESEE EDLPVGDEVC KRGYLRKQKH GHRRYFVLKL ETADAPARLE YYENARKFRH
SVRAAAAAAA AAASGAAVPA LIPPRRVITL YQCFSVSQRA DARYRHLIAL FTQDEYFAMV
AENESEQESW YLLLSRLILE SKRRRCGTLG AQPDGEPAAL AAAAAAEPPF YKDVWQVVVK
PRGLGHRKEL SGVFRLCLTD EEVVFVRLNT EVASVVVQLL SIRRCGHSEQ YFFLEVGRST
VIGPGELWMQ VDDCVVAQNM HELFLEKMRA LCADEYRARC RSYSISIGAH LLTLLSARRH
LGLLPLEPGG WLRRSRFEQF CHLRSIGDGE DEMLFTRRYV TPSEPLHPSR QGRLHLPRGR
RSRRAVSVPA SFLRRLAPSP VRAPHPEEDP NNRACEASGS DSGNSGRKGK EVKQSQEGSE
GDYMPMNNWG SGNGRGSGGG QGSSGQGSSS GRQGSGGGQG SSGGQGSGGQ SGGGNQCSGD
GQGTAGGHGS GGGQRPGGGP GSGGGQGPGD GGKGSGSGKS SDGDGDRGKS LKKRSYFGKL
TQSKQQQIPP PPPPPPPPPP AGTTSGKGKS GGRFRLYFCA DRGATKERKE AKEVRDTETL
EGAARGPHRA RAFDEDEDDP YVPMRPGVAA PLASSSDYMP MAPQNVSASK KRHSQSPFED
SRGYMMMFPR VSPPPAPSPP KAPDPNKEDD SKDNDSDSDY MFMAPGAGAI PKNPRNPQGG
SSSKSWSSYF SLPNPFQSSP LGQSDHSEYV PMLPGKFLGR GLDKEASSNW GPKDAPAKPS
AEGSFSKPRD GESPSKPLDD GPPKDKAKRP NRLSFMIKGN KIKPKPQKPT QEQREADSSS
DNVNIDFIKR DSNMSAPCAQ GLPDSWGIIA NPRRPAFSNY VNIEFGVPFP NPASRLSDLL
RAIPGANPLS LDGARWPLRP LPPNATGSNA NMPEGEYIEV IFNPAMTPAV PFADRAIRYD
AETGRIYVVD PFSECCMDVS LSPSRSSEPP PVARLLQEEE QRRRRSQSPT PSFFAAARAV
VSAFPTDSFE RDLSAAPSLA AAPAAAPTLA VGRALAAASA LAAVPGIGAA AAGLEAAAGF
DSASTRWFLP VANAAAAEPV RGAQDIAEGA NPGVPDPAAD LAGAAAAAPP PPPCHRLGPR
PPEREDSEDE DEDDTYVRMD FARPDNKK
//
