ID I3NFB6_ICTTR Unreviewed; 625 AA.
AC I3NFB6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=SH2B adaptor protein 2 {ECO:0000313|Ensembl:ENSSTOP00000023063.2};
GN Name=SH2B2 {ECO:0000313|Ensembl:ENSSTOP00000023063.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023063.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023063.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
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DR EMBL; AGTP01053287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3NFB6; -.
DR Ensembl; ENSSTOT00000029468.2; ENSSTOP00000023063.2; ENSSTOG00000024384.2.
DR GeneTree; ENSGT00950000183191; -.
DR HOGENOM; CLU_014885_5_0_1; -.
DR TreeFam; TF323184; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10411; SH2_SH2B2; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035058; SH2B2_SH2.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF4; SH2B ADAPTER PROTEIN 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 182..295
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 411..509
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 141..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 67062 MW; D2D7F82A2F498CFB CRC64;
MNGADPGAAA ATPVPVPDWR QFCELHAQVA AVDFAHKFCR FLRDNPAYDT PDAGTSFSRH
FTANFLDVFS EEVRRMLRAN AMEPEPVGTS ALKTTAYGHS RSSEDVSAHV AAKARVRKGF
SLRNMSLCVV DGVRDMWHRR ASPEPEAGAT PRAAEPPAEP RDKWTRRLRL SRTLAAKVEL
VDIQREGALR FMVADDAATG PGGAAQWQKC RLLLRRAVAG ERFRLEFFVP PKASRPKVSI
PLSAIIEVRT TMPLEMPEKD NTFVLKVENG AEYILETIDS LQKHSWVADI QGCVDPGDSE
EDAELSCARG ACLASRVASC SCELLTDAAD PPRPQGPQDT AAAVGAVVTA PHSRAREAVG
ESLLHVPLET FLQTLESPSG SGSDGNNAGE EGAAEQDPEA EPELELSDYP WFHGTLSRVK
AAQLVLAGGP RSHGLFVIRQ SETRPGEYVL TFNFQGKAKH LRLSLNGHGQ CHVQHLWFQS
VLDMLRHFHT HPIPLESGGS ADITLRSYVR AQGPPPDPGP SPSTVPAPSA CWTESAGQHY
FSSLVSASCP PASPSDAAGA SSSSASSSSA ASVPAPPRPA EVPLSARSRS NSAERLLEAA
AGAPDETPDA APGRARAVEN QYSFY
//
