ID I3NGC0_ICTTR Unreviewed; 1696 AA.
AC I3NGC0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Unc-13 homolog A {ECO:0000313|Ensembl:ENSSTOP00000023417.2};
GN Name=UNC13A {ECO:0000313|Ensembl:ENSSTOP00000023417.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000023417.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000023417.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01071336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01071337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01071338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01071339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01071340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSTOT00000027458.2; ENSSTOP00000023417.2; ENSSTOG00000026062.2.
DR eggNOG; KOG1011; Eukaryota.
DR GeneTree; ENSGT00940000161905; -.
DR HOGENOM; CLU_018378_0_0_1; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:UniProt.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF1; PROTEIN UNC-13 HOMOLOG A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..97
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 554..604
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 660..784
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1094..1237
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1346..1504
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1518..1645
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 185..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..367
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..421
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1696 AA; 192387 MW; A292DA1661265F72 CRC64;
PSLSLSTVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG SQPSWEQDFM FEINRLDLGL
TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD SQVIMADSEI CGTKDPTFHR
ILLDTRFELP LDIPEEEARY WAKKLEQLNT LRDQDEYSFH DEQDKPLPVP SSQCCNWNYF
GWGEQNDDPD SAVDDRDSDY RSETSNSIPP PYYTTSQPNA SVHQYSVRPP PLGSRESYSD
SMHSYEEFSE ARVLSPTGSS HYASSGELSQ GSSQLSEDFD PDEQSLQGSE LEDERDRDSY
HSCHSSVSYH KDSPRWDQDE EDLEEDLEED LEEDLEEDLE DEELPEEEEE EEEEEEEVEE
EEEVYVQQES VAAEPKDFKR LSHPPAAPEK EDKAPTLPTE APDVPKATSK PPTPEEVPGA
PEPEPPKAEE SFRPREDEEG QEGQDSMSRA KANWLRAFNK VRMQLQEARG EGEMSKSLWF
KGGPGGGLII IDSMPDIRKR KPIPLVSDLS LVQSRKAGIT SALASSTLNN EELKNHVYKK
TLQALIYPIS CTTPHNFEVW TATTPTYCYE CEGLLWGIAR QGMRCTECGV KCHEKCQDLL
NADCLQRAAE KSSKHGAEDR TQNIIMVLKD RMKIRERNKP EIFELIQEIF AVTKTAHTQQ
MKAVKQSVLD GTSKWSAKIS ITVVCAQGLQ AKDKTGSSDP YVTVQVGKTK KRTKTIYGNL
NPVWEENFHF ECHNSSDRIK VRVWDEDDDI KSRVKQRFKR ESDDFLGQTI IEVRTLSGEM
DVWYNLDKRT DKSAVSGAIR LHISVEIKGE EKVAPYHVQY TCLHENLFHF VTDVQNNGVV
KIPDAKGDDA WKVYYDETAQ EIVDEFAMRY GVESIYQAMT HFACLSSKYM CPGVPAVMST
LLANINAYYA HTTASTNVSA SDRFAASNFG KERFVKLLDQ LHNSLRIDLS MYRNNFPASS
PERLQDLKST VDLLTSITFF RMKVQELQSP PRASQVVKDC VKACLNSTYE YIFNNCHELY
SREYQTDPAK KGEVPPEEQG PSIKNLDFWS KLITLIVSII EEDKNSYTPC LNQFPQELNV
GKISAEVMWN LFAQDMKYAM DEHDKHRLCK SADYMNLHFK VKWLYNEYVA ELPAFKDRVP
EYPAWFEPFV IQWLDENEEV SRDFLHGALE RDKKDGFQQT SEHALFSCSV VDVFSQLNQS
FEIIKKLECP DPQIVGHYMR RFAKTISNVL LQYADIISKD FASYCSKEKE KVPCILMNNT
QQLRVQLEKM FEAMGGKELD AEASDILKEL QVKLNNVLDE LSRVFATSFQ PHIEECVKQM
GDILSQVKGT GNVPASACSS VAQDADNVLQ PIMDLLDSNL TLFAKICEKT VLKRVLKELW
KLVMNTMEKT IVLPPLTDQT GTLLRKHGKG LEKVMRGTQM IFNAAKELGQ LSKLKDHMVR
EEAKSLTPKQ CAVVELALDT IKQYFHAGGV GLKKTFLEKS PDLQSLRYAL SLYTQATDLL
IKTFVQTQGA QGSGVEDPVG EVSVHVELFT HPGTGEQKVT VKVVAANDLK WQTSGIFRPF
IEVNIIGPQL SDKKRKFATK SKNNSWAPKY NESFQFTLSA DAGPECYELQ VCVKDYCFAR
EDRTVGLAVL QLRELAQRGS AACWLPLGRR IHMDDTGLTV LRILSQRSND EVAKEFVKLK
SDTRSAEEGG GAAPAP
//
