ID I3PMM6_9ADEN Unreviewed; 1254 AA.
AC I3PMM6;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=DNA polymerase {ECO:0000256|PIRNR:PIRNR000788, ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|PIRNR:PIRNR000788, ECO:0000256|RuleBase:RU000442};
GN Name=pol {ECO:0000313|EMBL:AFC40566.1};
OS Goose adenovirus 4.
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Aviadenovirus; Goose aviadenovirus A.
OX NCBI_TaxID=1193422 {ECO:0000313|EMBL:AFC40566.1, ECO:0000313|Proteomes:UP000107383};
RN [1] {ECO:0000313|EMBL:AFC40566.1, ECO:0000313|Proteomes:UP000107383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P29 {ECO:0000313|EMBL:AFC40566.1};
RX PubMed=20159738;
RA Ivanics E., Palya V., Markos B., Dan A., Ursu K., Harrach B., Kajan G.,
RA Glavits R.;
RT "Hepatitis and hydropericardium syndrome associated with adenovirus
RT infection in goslings.";
RL Acta Vet. Hung. 58:47-58(2010).
RN [2] {ECO:0000313|EMBL:AFC40566.1, ECO:0000313|Proteomes:UP000107383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P29 {ECO:0000313|EMBL:AFC40566.1};
RX PubMed=22894926; DOI=10.1099/vir.0.042028-0;
RA Kajan G.L., Davison A.J., Palya V., Harrach B., Benko M.;
RT "Genome sequence of a waterfowl aviadenovirus, goose adenovirus 4.";
RL J. Gen. Virol. 93:2457-2465(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|PIRNR:PIRNR000788, ECO:0000256|RuleBase:RU000442};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|PIRNR:PIRNR000788,
CC ECO:0000256|RuleBase:RU000442}.
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DR EMBL; JF510462; AFC40566.1; -; Genomic_DNA.
DR RefSeq; YP_006383556.1; NC_017979.1.
DR GeneID; 12978937; -.
DR KEGG; vg:12978937; -.
DR Proteomes; UP000107383; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR014382; DNA-dir_DNA_pol_B_adenovir.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR PIRSF; PIRSF000788; DPol_ADV; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|PIRNR:PIRNR000788,
KW ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR000788, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|PIRNR:PIRNR000788};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|PIRNR:PIRNR000788};
KW Reference proteome {ECO:0000313|Proteomes:UP000107383};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000788};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 416..909
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
FT REGION 897..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1202..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 145276 MW; B6D738A0D7974358 CRC64;
MEEFDMDWIS DEELQTYDAP SETCDKDPPD PIFCSYPARP SNKNKNYPVP IIHSKIGRDS
LHIRTLPPKQ IKEMNKLFRS MVGKLVKCGV YYYQGEPYKI RATPFMKGLR KYLTLHKFLG
SNHRHYKRID YSFYAENPIE RLSVFKPSNI QLVQLRGKTA TIQKQWQCDT PVMPPIMITR
DLEPGEWTWI ASFKPLNKCP SCGICWTNKH SCKEASTSFY WMSIDKTGRE MWQHVRFKCA
SSPPNNRNLF VTYDIETYTI FTERGKRMYP FMLCFKLSGD PILVQQAEEI AKQDTSIGTI
NGGYYWIHND PGVVGRKFRN FRTNLQVYFA DDLIFRFFQF NSKPIEALLK EKKLKNPRDL
PFDVYWEHRK KFFVPSEFYQ VSIIVIGHNI CKFDEILLAS EIIEDREIYP KATKCERAFM
PRAGRLLFND IYFSLPNPSY LDKDPTRTMR WKRARTENND YMFLSVKFTV RDTCQLTGGA
SLRKAAQAYS LNASKGECPY EAINDFLSTG QYKKDEDGFP QTEYWQNETV MLEQKQLWQA
NHPSQPYDII HACLEYCMLD VIVTEQLAHT ILHNYDVYFK VELGFEGNFN IFERPTIPSN
THALWKQLAF AEYIQEKQSS PLNQLKNIDH RFVAQLYSPH KTMFKYIRQA LRGGRCYPTI
LGPFYKPVYV FDICGMYASA LTHPLPHGSP LDPKSTAIHV DILNSILQGQ ETISYFDSRI
KPSILKVEAH PPCITQLDSL PPICSRKGGR LVWTNESLYD EVITVIDIIT LHNRGWKVKV
IHDPMNVVFR EWKTLCAEYV GKNIRAKEKA DKEGNEIMRS ISKLLSNALY GAFATNMDTT
KIIFEQDLSQ EDMEKIHFGD LEVNHVTVLN DPSFKKQIAF TENAFSSLLL GRDFNSPWSS
AEDEEEEDTR KDQRSLTSSP SLEDIDEELL DLNARPYIPS EEYDHAHFTA ASTTRFKPLT
LLEAPSEALT ILHVEKQDKM VENNRYATQL ACFVLGWSRA FFSEWADIVH GPDRGTHPHE
REPQSLYGDT DSIFLTESGY KRMITRGAHR IKSPSTQLIF DPKNPQLTWA CECDIKCKQC
KSDTYSSESI YLAPKLYALK DSHCTKCGFV GQGKLRAKGH PGEELIYDTL MRCWQRSEEE
AITGTSSIPE LNTSRTIFKK TLLNKVSKYD PFTLHNERLT RVLRPWKDIT LYQHGDYLYP
YNNANPNPRN ELPSRQLEDF SGDDPLQPLT GEDCDILLDF IKENDGNQEE ALEL
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